Protein Alignment pb and ALX1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 239
• Identity: 60/239 - (25%)
• Similarity: 95/239 - (39%)
• Gaps: 48/239 - (20%)

  Fly   158 GMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKY 222
            ||....|...:.:|..|..||:..                 ||.||.:|:.||.||||.|....|
Human   109 GMQEKGELDELGDKCDSNVSSSKK-----------------RRHRTTFTSLQLEELEKVFQKTHY 156

  Fly   223 LCRPRRIEIAASLDLTERQVKVWFQNRRMK-HKRQTLSKTDDEDNKDSLKGDDD---QSDS---- 279
            .....|.::|...:|||.:|:|||||||.| .||:...:.....:..:...|..   ::||
Human   157 PDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQI 221

  Fly   280 -------NSNSKKSCQGCELPSDDIPDSTSNSRGHNNNTPSA---TNNNPSAGNLTPNSSLETGI 334
                   |::.......|.||.|  ..|......|:..|.|:   .:|:.:..:..|.::..|
Human   222 QNNLWAGNASGGSVVTSCMLPRD--TSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFT-- 282

  Fly   335 SSNLMGSTTVSASNVISADSSVASSVSLDEDIEESSPIKVKKKD 378
            .|.|.|:|...|..........:||:::         :::|.|:
Human   283 DSLLTGATNGHAFETKPEFERRSSSIAV---------LRMKAKE 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	27/56 (48%)
ALX1	NP_008913.2	Homeodomain	133..189	CDD:459649	27/55 (49%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		24/139 (17%)
		OAR	302..320	CDD:461067	4/25 (16%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		4/21 (19%)