DRSC/TRiP Functional Genomics Resources

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Protein Alignment pb and Nkx6-1

DIOPT Version :10

Sequence 1:NP_476669.3 Gene:pb / 40826 FlyBaseID:FBgn0051481 Length:782 Species:Drosophila melanogaster
Sequence 2:NP_113925.1 Gene:Nkx6-1 / 65193 RGDID:69318 Length:365 Species:Rattus norvegicus


Alignment Length:338 Identity:90/338 - (26%)
Similarity:132/338 - (39%) Gaps:104/338 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TSMGTQIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGV-----GGVGVSVGQP----------G 60
            :|..:...|.||..||               ||...||:     ||:. |:|.|          |
  Rat    49 SSSSSSSSSSSPSPPL---------------GAHNPGGLKPPAAGGLS-SLGSPPQQLSAATPHG 97

  Fly    61 IG---QQGVPPVPSVLMVNKMTPNCDKRSADTAYWMT-----------------ASEGGFINSQP 105
            |.   .:...||.|...:...:|:....|:.::...|                 :|..|.:...|
  Rat    98 INDILSRPSMPVASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLP 162

  Fly   106 SMAEFLNHLSPESPKIG---TPVGSGAIGGVGVNVNVNVGVGVGY--PVGVVP-QTP---DGMDS 161
            ..:.    |||..|..|   :| .:.|:..||           .|  |:..:| :||   .|:..
  Rat   163 RFSS----LSPPPPPPGLYFSP-SAAAVAAVG-----------RYPKPLAELPGRTPIFWPGVMQ 211

  Fly   162 VPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRP 226
            .|  ||     ...:.:...:||  ||  .:.::|..:..|..::..|:..|||.|...|||..|
  Rat   212 SP--PW-----RDARLACTPHQG--SI--LLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGP 265

  Fly   227 RRIEIAASLDLTERQVKVWFQNRRMKHKRQ------TLSKTDDEDNKDSLKG-------DDDQS- 277
            .|..:|.||.:||.||||||||||.|.:::      |..|..|.:. :.|||       |||.: 
  Rat   266 ERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSET-ERLKGTSENEEDDDDYNK 329

  Fly   278 --DSNSNSKKSCQ 288
              |.||:.:|..|
  Rat   330 PLDPNSDDEKITQ 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pbNP_476669.3 Homeodomain 199..255 CDD:459649 27/55 (49%)
Nkx6-1NP_113925.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..136 23/102 (23%)
Repressor domain. /evidence=ECO:0000250 102..269 43/193 (22%)
Homeodomain 236..294 CDD:459649 27/57 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 14/49 (29%)
Involved in DNA-binding. /evidence=ECO:0000250 307..365 12/37 (32%)

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