Protein Alignment pb and SHOX2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_003021.3
• Gene: SHOX2 / 6474
• HGNCID: 10854
• Length: 355
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 93/397 - (23%)
• Similarity: 145/397 - (36%)
• Gaps: 111/397 - (27%)

  Fly    16 QIKSESPLNPLQVQTGQT-------SLP----VGGCGGAGVVGGVGGVGVSVGQPGIG---QQGV 66
            ::....||...:..||.|       |.|    .||.||.|..||.||.|..||..|.|   ..|.
Human    27 EVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGGR 91

  Fly    67 PPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIG 131
            .||               |..|    |.|:|.......|.:.|  ....|...::...:   .:.
Human    92 SPV---------------RELD----MGAAERSREPGSPRLTE--GRRKPTKAEVQATL---LLP 132

  Fly   132 GVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENG 196
            |......|:                         |.:|::|...|..  .::|...|.:
Human   133 GEAFRFLVS-------------------------PELKDRKEDAKGM--EDEGQTKIKQ------ 164

  Fly   197 LPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKT 261
              ||.||.:|..||.|||:.|....|.....|.|::..|.|:|.:|:|||||||.|.::|
Human   165 --RRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQ----- 222

  Fly   262 DDEDNKDSLKGDDD--------------------QSDSNSN-SKKSCQ-GCELPSDDIPDSTSNS 304
            :::.:|..|.|...                    |.||:.| :..|.| ..:|..|     ::.:
Human   223 ENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLD-----SAVA 282

  Fly   305 RGHNNNTPSATNNNPSAGNLTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEES 369
            ..|::..|....:.|......|    ..|:....:.:.:.||::|::| ::.|.:.|.:..|.:.
Human   283 HAHHHLHPHLAAHAPYMMFPAP----PFGLPLATLAADSASAASVVAA-AAAAKTTSKNSSIADL 342

  Fly   370 SPIKVKK 376
            . :|.||
Human   343 R-LKAKK 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	26/55 (47%)
SHOX2	NP_003021.3	Homeodomain	165..221	CDD:459649	26/55 (47%)
		OAR	335..351	CDD:461067	4/15 (27%)