Protein Alignment pb and Pitx2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001035970.1
• Gene: Pitx2 / 54284
• RGDID: 3331
• Length: 324
• Species: Rattus norvegicus
• Alignment Length: 280
• Identity: 74/280 - (26%)
• Similarity: 116/280 - (41%)
• Gaps: 46/280 - (16%)

  Fly   151 VVPQTPDGMD-----------SVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTA 204
            :.|..|..:|           |....|.:.||...::..|.:...::.     .:....||.||.
  Rat    39 LAPGQPRSLDASKHRLEVHTISDTSSPEVAEKDKGQQGKNEDVGAEDP-----SKKKRQRRQRTH 98

  Fly   205 YTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDS 269
            :|:.||.|||..|..|:|.....|.|||...:|||.:|:|||:|||.|.:::       |.|:
  Rat    99 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKR-------ERNQ-- 154

  Fly   270 LKGDDDQSDSNSNS-KKSCQGCELPSDDI-PDSTSNSRGHNNNTPS--ATNNNP--SAGNLTPNS 328
                  |::...|. .....|...|.||: |..:.|:......|.:  :|.:.|  ::.|:.|.|
  Rat   155 ------QAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLS 213

  Fly   329 SLETGISSNLMGSTTVSASNVISADSSVASSV--SLDEDIEESSPIKVKKKDDGQVIKKEAVSTS 391
            |.......|.:.|.::|:|.|.||.:.|..|.  ||:.....|||      .....:...|...:
  Rat   214 SQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSP------SLNSAVPTPACPYA 272

  Fly   392 SKASPFGYENS-TPSLVSFR 410
            ....|:.|.:: ..||.|.|
  Rat   273 PPTPPYVYRDTCNSSLASLR 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	28/55 (51%)
Pitx2	NP_001035970.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..111		15/58 (26%)
		Homeodomain	93..149	CDD:459649	28/55 (51%)
		OAR	282..299	CDD:461067	4/11 (36%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	286..299		4/7 (57%)
		Nuclear localization signal. /evidence=ECO:0000255	292..296		1/1 (100%)