Protein Alignment pb and PITX3

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 53/214 - (24%)
• Similarity: 89/214 - (41%)
• Gaps: 48/214 - (22%)

  Fly   160 DSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENG----LPRRLRTAYTNTQLLELEKEFHFN 220
            |:...:|.:.|.....:..:::.:...|:....||:|    ..||.||.:|:.||.|||..|..|
Human    20 DAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRN 84

  Fly   221 KYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKK 285
            :|.....|.|||...:|||.:|:|||:|||.|.:::                      ..|...:
Human    85 RYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKR----------------------ERSQQAE 127

  Fly   286 SCQGCEL--------PSDDIPDSTSNSRGHNNNTPSATNNNPSAGNLTPNSSLET-GISSNLMGS 341
            .|:|...        |.:::....|    :.|..|.|         |.|..:.:| ..:.|.:..
Human   128 LCKGSFAAPLGGLVPPYEEVYPGYS----YGNWPPKA---------LAPPLAAKTFPFAFNSVNV 179

  Fly   342 TTVSASNVISADSSVASSV 360
            ..:::..|.|..||:|:|:
Human   180 GPLASQPVFSPPSSIAASM 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	28/55 (51%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		11/50 (22%)
		Homeodomain	63..119	CDD:459649	28/55 (51%)
		OAR	258..275	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272