Protein Alignment pb and PITX2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 75/280 - (26%)
• Similarity: 116/280 - (41%)
• Gaps: 46/280 - (16%)

  Fly   151 VVPQTPDGMDSV-----------PEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTA 204
            :.|..|..:||.           ...|...||..|::..|.:...::.     .:....||.||.
Human    39 LAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQQGKNEDVGAEDP-----SKKKRQRRQRTH 98

  Fly   205 YTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDS 269
            :|:.||.|||..|..|:|.....|.|||...:|||.:|:|||:|||.|.:::       |.|:
Human    99 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKR-------ERNQ-- 154

  Fly   270 LKGDDDQSDSNSNS-KKSCQGCELPSDDI-PDSTSNSRGHNNNTPS--ATNNNP--SAGNLTPNS 328
                  |::...|. .....|...|.||: |..:.|:......|.:  :|.:.|  ::.|:.|.|
Human   155 ------QAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLS 213

  Fly   329 SLETGISSNLMGSTTVSASNVISADSSVASSV--SLDEDIEESSPIKVKKKDDGQVIKKEAVSTS 391
            |.......|.:.|.::|:|.|.||.:.|..|.  ||:.....|||      .....:...|...:
Human   214 SQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSP------SLNSAVPTPACPYA 272

  Fly   392 SKASPFGYENS-TPSLVSFR 410
            ....|:.|.:: ..||.|.|
Human   273 PPTPPYVYRDTCNSSLASLR 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	28/55 (51%)
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	28/55 (51%)
		OAR	282..299	CDD:461067	4/11 (36%)