Protein Alignment pb and NKX3-1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_006158.2
• Gene: NKX3-1 / 4824
• HGNCID: 7838
• Length: 234
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 64/242 - (26%)
• Similarity: 99/242 - (40%)
• Gaps: 51/242 - (21%)

  Fly    56 VGQPGIGQQ----GVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSP 116
            |.:|..|:.    ..||.||..:.:.:..:..:..|.       .:||..:||       ....|
Human     4 VPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQ-------RQGGRTSSQ-------RQRDP 54

  Fly   117 ESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNN 181
            |......|.|..:..|...:                 |...|..:.||     |.:|..::....
Human    55 EPEPEPEPEGGRSRAGAQND-----------------QLSTGPRAAPE-----EAETLAETEPER 97

  Fly   182 NQGDNSITEFVPENGLPR----------RLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLD 236
            :.|...:........|||          |.|.|:::||::|||::|...|||..|.|..:|.:|.
Human    98 HLGSYLLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLK 162

  Fly   237 LTERQVKVWFQNRRMKHKRQTL-SKTDDEDNKDSLKGDDDQSDSNSN 282
            |||.|||:||||||.|.||:.| |:..|.:...||....:::.|.::
Human   163 LTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALKEEAFSRAS 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	30/65 (46%)
NKX3-1	NP_006158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		29/162 (18%)
		Homeodomain	125..181	CDD:459649	29/55 (53%)