Protein Alignment pb and MSX1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_002439.2
• Gene: MSX1 / 4487
• HGNCID: 7391
• Length: 303
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 73/282 - (25%)
• Similarity: 111/282 - (39%)
• Gaps: 89/282 - (31%)

  Fly    33 TSLPVG-----GCGGAGVVGGVG----GVGVSVGQPGIGQQGVPP--VPSV-------LMVNKMT 79
            ||||:|     ...|....||.|    ....:....|..::|..|  .||:       ||.:...
Human     8 TSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATAAAMGADEEGAKPKVSPSLLPFSVEALMADHRK 72

  Fly    80 PNCDKRSADTAYWMTASEGGFINSQP------SMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVN 138
            |...:.:...:..:.|:.|   ::||      |:.      :|::|....|:|..::||:
Human    73 PGAKESALAPSEGVQAAGG---SAQPLGVPPGSLG------APDAPSSPRPLGHFSVGGL----- 123

  Fly   139 VNVGVGVGYPVGVV-----PQTPDGMDSVPEYPWMKEKK--------------TSRKSSNNNNQG 184
                  :..|...:     |:.|:      ..|||:..:              |.||...|
Human   124 ------LKLPEDALVKAESPEKPE------RTPWMQSPRFSPPPARRLSPPACTLRKHKTN---- 172

  Fly   185 DNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNR 249
                          |:.||.:|..|||.||::|...:||....|.|.::||.|||.|||:|||||
Human   173 --------------RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNR 223

  Fly   250 RMKHKRQTLSKTDDEDNKDSLK 271
            |.|.||  |.:.:.|..|.:.|
Human   224 RAKAKR--LQEAELEKLKMAAK 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	29/55 (53%)
MSX1	NP_002439.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..55		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..117		9/56 (16%)
		PTZ00449	<105..>248	CDD:185628	51/176 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..174		9/64 (14%)
		Homeodomain	173..229	CDD:459649	29/55 (53%)