Protein Alignment pb and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: XP_038962557.1
• Gene: Nkx2-4 / 366213
• RGDID: 1304985
• Length: 353
• Species: Rattus norvegicus
• Alignment Length: 355
• Identity: 87/355 - (24%)
• Similarity: 121/355 - (34%)
• Gaps: 95/355 - (26%)

  Fly    23 LNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGIGQQGVPPVPSVLMVNKMTP-----NC 82
            |:|::    :|....||.    :.|...|:|..:|..........|......|..|.|     ..
  Rat    17 LSPIE----ETYKKFGGV----MDGAPPGLGAPLGAAAYRAPPTGPSSQAAAVAGMQPPHAMAGH 73

  Fly    83 DKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGY 147
            :..:|..|....|:.....:..|.:::|     |.|     .:||...||:|
  Rat    74 NAAAAAAAAAAAAAAAATYHMPPGVSQF-----PHS-----AMGSYCNGGLG------------- 115

  Fly   148 PVGVVPQTPDGM--------------DSVPEYPWMKEKKTSR---KSSNNNNQGDNSIT------ 189
            .:|.:|...|||              ::.|.|     ...||   .|:..|..|..|:|
  Rat   116 NMGELPAYTDGMRGGAAAAATGWYGANTDPRY-----SSISRFMGPSAGVNVAGMGSLTGIADAA 175

  Fly   190 -EFVP-ENGLPRR-LRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRM 251
             ...| ....||| .|..::..|:.|||:.|...|||..|.|..:|:.:.||..|||:||||.|.
  Rat   176 KSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRY 240

  Fly   252 KHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSK----------KSCQGCELPSDDIPDSTSNSRG 306
            |.|||...|...:..::...|........|..:          |.||                .|
  Rat   241 KMKRQAKDKAAQQLQQEGGLGPPPPPPPPSPRRVAVPVLVKDGKPCQ----------------NG 289

  Fly   307 HNNNTPSATNNNPSAGNLTPNSSLETGISS 336
            ....||......|.|.  ||.|.||...||
  Rat   290 AGTPTPGQGGQQPQAP--TPASELEELSSS 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	25/56 (45%)
Nkx2-4	XP_038962557.1	Homeodomain	188..244	CDD:459649	24/55 (44%)