Protein Alignment pb and PDX1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 72/212 - (33%)
• Similarity: 92/212 - (43%)
• Gaps: 56/212 - (26%)

  Fly    57 GQPGIGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKI 121
            |..|..:||.||..|...|..:        ||               .|::|...:||..:....
Human    52 GALGALEQGSPPDISPYEVPPL--------AD---------------DPAVAHLHHHLPAQLALP 93

  Fly   122 GTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVP-EYPWMKEKKTSRKSSNNNNQGD 185
            ..|.|.                   :|.|..|...:..:.|. .:||||    |.|:.....|..
Human    94 HPPAGP-------------------FPEGAEPGVLEEPNRVQLPFPWMK----STKAHAWKGQWA 135

  Fly   186 NSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRR 250
            .......||..  :|.|||||..|||||||||.||||:.||||:|:|..|:||||.:|:||||||
Human   136 GGAYAAEPEEN--KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRR 198

  Fly   251 MKHKRQTLSKTDDEDNK 267
            ||.|:       :||.|
Human   199 MKWKK-------EEDKK 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	39/55 (71%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		7/18 (39%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeodomain	147..203	CDD:459649	39/55 (71%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		4/15 (27%)