DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and HOXD3

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	398	Identity:	113/398 - (28%)
Similarity:	155/398 - (38%)	Gaps:	106/398 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSLDTTSMGT--QIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGIGQQGVPP 68
            |||||...|:  .|:|.:||.....:..:.:   |.|...|.....||.|.| ..||:..:..||
Human    57 SSLDTDYPGSACSIQSSAPLRAPAHKGAELN---GSCMRPGTGNSQGGGGGS-QPPGLNSEQQPP 117

  Fly    69 VPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGV 133
            .|                                  |.....|...||.:|           ||
Human   118 QP----------------------------------PPPPPTLPPSSPTNP-----------GG- 136

  Fly   134 GVNVNVNVGVGVGYPVGVVPQTPDGMDSVPE--YPWMKEKKTSRKSSNNNNQGDNSITEFVPENG 196
                    ||....|.| .|.......::.:  :|||||.:.:.|..|:......|..:..|...
Human   137 --------GVPAKKPKG-GPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGP 192

  Fly   197 LPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKT 261
            ..:|:|||||:.||:|||||||||:|||||||:|:|..|:|||||:|:||||||||:|:
Human   193 ASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK------ 251

  Fly   262 DDEDNKDSLKGDDDQSDSNSNSKKSCQG-----CELP-----SDDIPDSTSNSRGHNNNTPSATN 316
             |:..|..|.....||...|.......|     .:||     :.|.|...:.::...|....|..
Human   252 -DQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAY 315

  Fly   317 NNP-----------SAGNLTPNSSLETG---ISSNLMGSTTVSASNVISADS------------S 355
            ..|           :|....|:.....|   .|:||.||......|.:.:.:            |
Human   316 TAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVESMAPASGPVFNLGHLS 380

  Fly   356 VASSVSLD 363
            ..||.|:|
Human   381 HPSSASVD 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	52/105 (50%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	40/51 (78%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		37/187 (20%)
		Antp-type hexapeptide	160..165		2/4 (50%)
		Homeobox	198..250	CDD:306543	40/51 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		6/26 (23%)
		DUF4074	369..430	CDD:315871	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4526
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860