DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and HOXD1

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_078777.1	Gene:	HOXD1 / 3231	HGNCID:	5132	Length:	328	Species:	Homo sapiens

Alignment Length:	274	Identity:	77/274 - (28%)
Similarity:	97/274 - (35%)	Gaps:	105/274 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PLQVQTGQTSL---------PVGGCGGA--------------GVVGGV----------------- 49
            |...|..|.:|         |....|||              ||:|..
Human    77 PAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFS 141

  Fly    50 -GGVGVSVGQPGIGQQGVP-PVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLN 112
             ||..:..||......|.| |.|:          |.|.|||      ...|.|..:.|:...:..
Human   142 GGGSFLLSGQVDYAAFGEPGPFPA----------CLKASAD------GHPGAFQTASPAPGTYPK 190

  Fly   113 HLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKS 177
            .:||.|                           |.|.           :...:.|||.|:.:.|.
Human   191 SVSPAS---------------------------GLPA-----------AFSTFEWMKVKRNASKK 217

  Fly   178 SNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQV 242
            ......|..|     |.:.    :||.::..||.||||||||||||.|.||||||..|.|.:.||
Human   218 GKLAEYGAAS-----PSSA----IRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQV 273

  Fly   243 KVWFQNRRMKHKRQ 256
            |:||||||||.|::
Human   274 KIWFQNRRMKQKKR 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	44/89 (49%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	36/51 (71%)
HOXD1	NP_078777.1	Antp-type hexapeptide	204..209		1/4 (25%)
		Homeobox	233..285	CDD:278475	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810