Protein Alignment pb and HOXA13

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_000513.2
• Gene: HOXA13 / 3209
• HGNCID: 5102
• Length: 388
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 65/262 - (24%)
• Similarity: 103/262 - (39%)
• Gaps: 63/262 - (24%)

  Fly    38 GGCGGAGVVGGVGGVGVS----VGQPGIGQQGVP-------PVPSVLMVNKMTPNCDKRSADTAY 91
            ||.|.||..|.......|    ..|...|...:|       ..|...|  ...||..|..|..|
Human   137 GGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYPCARM--GPHPNAIKSCAQPA- 198

  Fly    92 WMTASEGGFIN-----SQPSMAEF------------------LNHLSPESPKIGTPVGSGAIGGV 133
             ..|:...|.:     :.|:..||                  .:|..|....:..||..| :||.
Human   199 -SAAAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHHHQPMPGYLDMPVVPG-LGGP 261

  Fly   134 GVNVNVNVGVGV-GYPVGVVPQTPDGM------DSVPEYPW---MKEKKTSRKSSNNNNQGDNSI 188
            |.:.:..:|:.: .|....:|...:|.      .:.|.:.|   :.:..:....:::..:|
Human   262 GESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPHLWKSTLPDVVSHPSDASSYRRG---- 322

  Fly   189 TEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKH 253
                      |:.|..||..||.|||:|:..||::.:.:|..|:|:.:|:||||.:||||||:|.
Human   323 ----------RKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKE 377

  Fly   254 KR 255
            |:
Human   378 KK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	27/55 (49%)
HOXA13	NP_000513.2	HoxA13_N	85..224	CDD:463521	22/90 (24%)
		Homeodomain	323..379	CDD:459649	27/55 (49%)