DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and HOXA4

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_002132.3	Gene:	HOXA4 / 3201	HGNCID:	5105	Length:	320	Species:	Homo sapiens

Alignment Length:	362	Identity:	98/362 - (27%)
Similarity:	133/362 - (36%)	Gaps:	131/362 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GCGGAGVVGGVGGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCD-------------------- 83
            |.|||.     ||.|   |.||..|...||...:.:.....|:..
Human    28 GSGGAD-----GGPG---GGPGYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAY 84

  Fly    84 --------KRSADTAYWMTASEGGFINSQPSMAE-------------FLNHL------SPESPKI 121
                    ..:||||| .....||....:|...|             ..:|:      .|..|:.
Human    85 PAAALYPAHGAADTAY-PYGYRGGASPGRPPQPEQPPAQAKGPAHGLHASHVLQPQLPPPLQPRA 148

  Fly   122 GTPV------GSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPE--YPWMKEKKTSRKSS 178
            ..|.      .:.|..||...     |.....|:.:..::|.|:.....  |||||:...|..:.
Human   149 VPPAAPRRCEAAPATPGVPAG-----GSAPACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNP 208

  Fly   179 NNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVK 243
            :.|             .|.|:|.|||||..|:||||||||||:||.|.||||||.:|.|:|||||
Human   209 SYN-------------GGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVK 260

  Fly   244 VWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRGHN 308
            :||||||||.|:         |:|                        ||         |::..:
Human   261 IWFQNRRMKWKK---------DHK------------------------LP---------NTKMRS 283

  Fly   309 NNTPSATNNNPSAGNLT-------PNSSLETGISSNL 338
            :|:.||:...|......       |:.|..|.:.|::
Human   284 SNSASASAGPPGKAQTQSPHLHPHPHPSTSTPVPSSI 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	50/105 (48%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	40/51 (78%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..77		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..168		11/66 (17%)
		Antp-type hexapeptide	194..199		3/4 (75%)
		Homeobox	218..271	CDD:278475	40/52 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..320		13/79 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810