Protein Alignment pb and HOXA3

DIOPT Version :9

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001371264.1
• Gene: HOXA3 / 3200
• HGNCID: 5104
• Length: 443
• Species: Homo sapiens
• Alignment Length: 733
• Identity: 151/733 - (20%)
• Similarity: 202/733 - (27%)
• Gaps: 352/733 - (48%)

  Fly     5 CSSLDTTSMGTQIK----SESPLNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGI---G 62
            ||....:|.|...|    ||:.|..|.....|..                    |:|:|.:   .
Human    50 CSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPP--------------------SLGEPPLHPPP 94

  Fly    63 QQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGS 127
            .|..||.|.........|.....:.......:..:....|..|:.|       .:||.:.:|..:
Human    95 PQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANA-------AKSPLLNSPTVA 152

  Fly   128 GAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKE------KKTSRKSSNNNNQGDN 186
            ..|                                  :|||||      :|||..||..:..||.
Human   153 KQI----------------------------------FPWMKESRQNTKQKTSSSSSGESCAGDK 183

  Fly   187 SITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRM 251
            |    .|.....:|.|||||:.||:|||||||||:|||||||:|:|..|:|||||:|:|||||||
Human   184 S----PPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRM 244

  Fly   252 KHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRGHNNNTPSATN 316
            |:|:       |:..|..|.....||.|.|              .:|
Human   245 KYKK-------DQKGKGMLTSSGGQSPSRS--------------PVP------------------ 270

  Fly   317 NNPSAGNLTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEESSPIKVKKKDDGQ 381
              |.||
Human   271 --PGAG----------------------------------------------------------- 274

  Fly   382 VIKKEAVSTSSKASPFGYENSTPSLVSFRRDSDASAVGNAPTSKAVGKKRFQSAANAIATPTPLS 446
                            ||.||..|||        ::|...|.|                 |.|.
Human   275 ----------------GYLNSMHSLV--------NSVPYEPQS-----------------PPPF- 297

  Fly   447 DSNSGNGSGGGPAGGYFPGYYPSPKQQQQVQQQQLHPQQQQLPQQQPQDYYGKYDIEFAASPHHN 511
             |....|:.|.|...| |...||                 ..|...||..|.........:|.::
Human   298 -SKPPQGTYGLPPASY-PASLPS-----------------CAPPPPPQKRYTAAGAGAGGTPDYD 343

  Fly   512 PHNKQQALHGEYLSPKPSSANFHQNSQQQQQNDHFYYNYNDTNGTPYLNHQQQHHHHAQHHQQQQ 576
            ||     .||                          ...|.:.|||:
Human   344 PH-----AHG--------------------------LQGNGSYGTPH------------------ 359

  Fly   577 HHQNHVADFEGPVNGPSNFNNGAYYDNMSFQQQAQAHQHQTVVFQQQQPHQPAAINHQHMHHLGN 641
                        :.|...|..|:|.:.||                   ...||.....|:.|..:
Human   360 ------------IQGSPVFVGGSYVEPMS-------------------NSGPALFGLTHLPHAAS 393

  Fly   642 GETYSALGLQMENCEGYNNFGAAGTGGGYYEAGQQPPIPATHGHGHHPHHVQVPAQAHAPIHAHH 706
            |..               ::|.||            |:.:.|.||..|..   |...:..:..||
Human   394 GAM---------------DYGGAG------------PLGSGHHHGPGPGE---PHPTYTDLTGHH 428

  Fly   707 NSAAIPGGVGVGPPPSHI 724
            .|   .|.:...|..:|:
Human   429 PS---QGRIQEAPKLTHL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	57/111 (51%)
		Homeobox	202..254	CDD:278475	40/51 (78%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..147		15/98 (15%)
		Antp-type hexapeptide	155..160		3/38 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..196		13/40 (33%)
		Homeobox	195..248	CDD:395001	40/52 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..338		36/251 (14%)
		DUF4074	378..441	CDD:404218	19/95 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..443		13/60 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4526
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860