DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and HOXA1

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_005513.2	Gene:	HOXA1 / 3198	HGNCID:	5099	Length:	335	Species:	Homo sapiens

Alignment Length:	348	Identity:	96/348 - (27%)
Similarity:	132/348 - (37%)	Gaps:	108/348 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CSSLDTTSMGTQIKSESP--------LNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQ--- 58
            |...|...:|..::..||        .:| |..|.|||               |.:|||...
Human    47 CGGDDRFLVGRGVQIGSPHHHHHHHHRHP-QPATYQTS---------------GNLGVSYSHSSC 95

  Fly    59 -PGIGQQ--GVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPK 120
             |..|.|  ..|..|..|          .:.||.:       ||:....|::         .|..
Human    96 GPSYGSQNFSAPYSPYAL----------NQEADVS-------GGYPQCAPAV---------YSGN 134

  Fly   121 IGTPV------GSGAIGG-VGVNVNVNVGVG--------VGYPVGVVP---------QTPDGMDS 161
            :.:|:      ..|..|| ||....::...|        ..|...:.|         ::|....|
Human   135 LSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETS 199

  Fly   162 VP--EYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLC 224
            .|  .:.|||.|:...|:......|         ..|.|..:||.:|..||.||||||||||||.
Human   200 SPAQTFDWMKVKRNPPKTGKVGEYG---------YLGQPNAVRTNFTTKQLTELEKEFHFNKYLT 255

  Fly   225 RPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSL--------KGDDDQSDSNS 281
            |.||:||||||.|.|.|||:||||||||.|::         .|:.|        .|:|::::.:|
Human   256 RARRVEIAASLQLNETQVKIWFQNRRMKQKKR---------EKEGLLPISPATPPGNDEKAEESS 311

  Fly   282 NSKKSCQGCELPSDDIPDSTSNS 304
            ....|......|.....|:.:.|
Human   312 EKSSSSPCVPSPGSSTSDTLTTS 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	50/113 (44%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	39/51 (76%)
HOXA1	NP_005513.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..83		6/22 (27%)
		Interaction with OGT. /evidence=ECO:0000250\|UniProtKB:P09022	75..203		34/169 (20%)
		COG5576	176..>286	CDD:227863	52/118 (44%)
		Antp-type hexapeptide	204..209		1/4 (25%)
		Homeobox	233..286	CDD:365835	39/52 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..335		13/63 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910