Protein Alignment pb and TLX1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: XP_011538046.1
• Gene: TLX1 / 3195
• HGNCID: 5056
• Length: 342
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 90/346 - (26%)
• Similarity: 139/346 - (40%)
• Gaps: 81/346 - (23%)

  Fly    27 QVQTGQTSLP--VGGC-----GGAGVVGGVGGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCDK 84
            ::|.|:..|.  |||.     ||:....|.||.| :.|..|.|..|.|
Human    39 RLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGAG-AYGTGGPGGPGGP----------------- 85

  Fly    85 RSADTAYWMTASEGGFINSQPSMAEF-LNHLSPESPKIGTPVGSGAIGGVG---------VNVNV 139
                      |..||..:..|....: :|......|  |...|.|:.||.|         |..:.
Human    86 ----------AGGGGACSMGPLTGSYNVNMALAGGP--GPGGGGGSSGGAGALSAAGVIRVPAHR 138

  Fly   140 NVGVGVGYP------VGVVPQTP--DGMDSVP--EYPWMKEKKTSRKSSNNNNQGDNSITEFVP- 193
            .:...|.:|      :..||..|  .|::::.  .:|||:..:...|..........::|..:.
Human   139 PLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGH 203

  Fly   194 --ENGLP---RRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKH 253
              :|..|   ::.||::|..|:.||||.||..|||....|..:|.:|.:|:.|||.||||||.|.
Human   204 PYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKW 268

  Fly   254 KRQTLSKTDDE---DNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRGHNNNTPSAT 315
            :|||..:.:.|   .|:..|     |....:..|...|  .||:|.:       ..||::..:..
Human   269 RRQTAEEREAERQQANRILL-----QLQQEAFQKSLAQ--PLPADPL-------CVHNSSLFALQ 319

  Fly   316 NNNPSAGNLTPNSSLETGISS 336
            |..|.:.:.|..:|: |.::|
Human   320 NLQPWSDDSTKITSV-TSVAS 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	27/55 (49%)
TLX1	XP_011538046.1	Homeodomain	214..270	CDD:459649	27/55 (49%)