Protein Alignment pb and VSX1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_055403.2
• Gene: VSX1 / 30813
• HGNCID: 12723
• Length: 365
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 85/407 - (20%)
• Similarity: 129/407 - (31%)
• Gaps: 149/407 - (36%)

  Fly    10 TTSMGTQIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGV---GGVGVSVG-QPGIGQQGVPP-- 68
            |..:|.:.:..:|..|.| .:|.....|..|.|.|:.|..   |.:.:.:| ..|.|.|  ||
Human    34 TDLLGLEAELPAPAGPGQ-GSGCEGPAVAPCPGPGLDGSSLARGALPLGLGLLCGFGTQ--PPAA 95

  Fly    69 --VPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIG 131
              .|.:|:            ||..:                      |.|..|:...|
Human    96 ARAPCLLL------------ADVPF----------------------LPPRGPEPAAP------- 119

  Fly   132 GVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQG-DNSITEFVPEN 195
                               :.|..|      |.....:::..|..:|:.::|. |.:..:..|..
Human   120 -------------------LAPSRP------PPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTL 159

  Fly   196 G--LPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMK------ 252
            |  ..||.||.:|..||.||||.|....|.....|..:|...:|.|.:::|||||||.|
Human   160 GKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREK 224

  Fly   253 -----------------------------------------------HKRQ--TLSKTDDEDNKD 268
                                                           ||:.  .:.|...||...
Human   225 RWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLA 289

  Fly   269 SLKGDDDQSDSNSNSKKSCQ-GCELPS-----DDIP-DSTSNSRGHNNNTPSATNNNPSAG-NLT 325
            .|.|.|...:.:|.|:...| |.:..|     :|:. |.:|::|......      :|.|| ...
Human   290 GLWGSDHFKEGSSQSESGSQRGSDKVSPENGLEDVAIDLSSSARQETKKV------HPGAGAQGG 348

  Fly   326 PNSSLETGISSNLMGST 342
            .||:...|.....:|:|
Human   349 SNSTALEGPQPGKVGAT 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	26/108 (24%)
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		1/2 (50%)
		Octapeptide motif	31..38		1/3 (33%)
		PRK14959	<47..>149	CDD:184923	29/170 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..167		12/85 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		0/4 (0%)
		Homeodomain	165..221	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..365		19/80 (24%)