DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and Hoxb3

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001100512.1	Gene:	Hoxb3 / 303488	RGDID:	1310780	Length:	429	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	102/351 - (29%)
Similarity:	142/351 - (40%)	Gaps:	67/351 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQP-SMAEFLN- 112
            ||.....|..|.|..| ||.|.......:..:. :|||       .|.....|:.| :.::.||
  Rat    16 GGYSSYPGSNGFGYDG-PPQPPFQAATHLEGDY-QRSA-------CSLQSLGNAAPHAKSKELNG 71

  Fly   113 -----HLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSV---PEYPWMK 169
                 .|:||  .:..|.||........:...|...|.|......|:.....:|.   ..:||||
  Rat    72 SCMRPGLAPE--PLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGASSNSTLTKQIFPWMK 134

  Fly   170 EKKTSRK------------------------SSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQL 210
            |.:.:.|                        ||.....|.....:..|.:...:|.|||||:.||
  Rat   135 ESRQTSKLKNSSPGTAEGCGGGGGGGGGGGSSSGGGGSGGGGGDKSPPGSAASKRARTAYTSAQL 199

  Fly   211 LELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDD 275
            :|||||||||:|||||||:|:|..|:|:|||:|:||||||||:|:...:|     ...|..|...
  Rat   200 VELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAK-----GLASSSGGPS 259

  Fly   276 QSDSNSNSKKSCQG------CELPSDDIPDSTSNSRGHNNNTPSATNNNPSAGNL--------TP 326
            .:.|.....:|..|      ...||.|.|...:.|:||.|.....:|..|.....        ||
  Rat   260 PAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFSKGHQNAYALPSNYQPPLKGCGAPQKYPPTP 324

  Fly   327 NSSLETGI---SSNLMGSTTVSASNV 349
            ....|:.:   :....|:.|:..|.|
  Rat   325 APEYESHVLQANGGAYGTPTMQGSPV 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	52/129 (40%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	39/51 (76%)
Hoxb3	NP_001100512.1	Homeobox	191..244	CDD:395001	39/52 (75%)
Hoxb3	NP_001100512.1	DUF4074	365..427	CDD:404218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810