DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and hoxb3a

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_571192.2	Gene:	hoxb3a / 30339	ZFINID:	ZDB-GENE-990415-104	Length:	417	Species:	Danio rerio

Alignment Length:	334	Identity:	96/334 - (28%)
Similarity:	139/334 - (41%)	Gaps:	73/334 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPE-SPKIGT------- 123
            ||.|......::..:|                    .:||:.. .:|..|: ||...|
Zfish    58 PPQPQHAKTKELNGSC--------------------MRPSLPP-EHHPPPQVSPPQNTVNVAATN 101

  Fly   124 ----PVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQG 184
                |.|||. |||..:...:........:...|.....:     :|||||.:.:.|..|::...
Zfish   102 ATQQPGGSGG-GGVAGSGGTSKSSSKSSSMATNPTLTKQI-----FPWMKESRQNTKQKNSSPSA 160

  Fly   185 DNSITE------FVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVK 243
            .::..|      ..|.:...:|.|||||:.||:|||||||||:|||||||:|:|..|:|:|||:|
Zfish   161 SSANAESSGGEKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIK 225

  Fly   244 VWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGC-----ELPSDDIPDSTSN 303
            :||||||||:|:...||     ...|..|....:.|.....:|..|.     .:.|.|.|...|.
Zfish   226 IWFQNRRMKYKKDQKSK-----GIGSSSGGPSPTGSPPLPMQSSAGFMNSMHSMGSYDAPSPPSF 285

  Fly   304 SRGHNN-NTPSATNNNP--------SAGNLTPN--------SSLETGISSNLMGSTTVSASNVIS 351
            ::.|.| ...|....||        ..||..|:        :|...| :.|:.||......|.:.
Zfish   286 NKPHQNAYAMSTAYQNPMKGCPPQQKYGNTPPDYDPHGLQGNSGNYG-TPNMQGSPVYVGGNYVD 349

  Fly   352 ADSSVASSV 360
            |..:...|:
Zfish   350 AMPATGPSM 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	52/111 (47%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	39/51 (76%)
hoxb3a	NP_571192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..135		18/98 (18%)
		Antp-type hexapeptide	140..145		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..184		5/36 (14%)
		Homeobox	184..236	CDD:278475	39/51 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..290		11/57 (19%)
		DUF4074	353..415	CDD:290032	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810