DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pb and hoxb2a

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_571191.1	Gene:	hoxb2a / 30338	ZFINID:	ZDB-GENE-990415-103	Length:	390	Species:	Danio rerio

Alignment Length:	376	Identity:	131/376 - (34%)
Similarity:	165/376 - (43%)	Gaps:	105/376 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 EGGFINSQPSMAEFL-------------------------NHLSPE-SPKIGT---PVGSGAIGG 132
            |.||||||||:||.|                         .|..|. ||..|.   |........
Zfish     8 EIGFINSQPSLAECLTSFPAVLESFQTSSIKDSTAIPPPFEHTIPSLSPCTGNQARPRSQKRTAS 72

  Fly   133 VGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRK------------------SSN 179
            .|:.:.........:..|..|.: .|.....|:|||||||:|:|                  ||.
Zfish    73 NGLQLRTQTAPPTQHQQGPAPLS-GGAPLAHEFPWMKEKKSSKKCPKPGATAAAAAASPSQASSG 136

  Fly   180 NNNQGDNSITEFVPENGL-----PRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTE 239
            ....|..|.||.  :.||     .||||||||||||||||||||||||||||||:||||.|||||
Zfish   137 YTTAGLESPTEI--QGGLDNVSGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTE 199

  Fly   240 RQVKVWFQNRRMKHKRQTLSKTDDEDNK----DSLKGDDDQSDSNSNS-KKSCQGCELPSDD--- 296
            ||||||||||||||||||....|.::.:    |.|:|.|..|..:|.| :.|..|...||:.
Zfish   200 RQVKVWFQNRRMKHKRQTTHHRDGQEGEPSGFDLLEGTDASSPYSSQSLEVSGSGSAAPSESETC 264

  Fly   297 -------------------------IPDSTSNSRGHNNNTPSATNNNP-------SAGNLTPNSS 329
                                     .|.|..::..|:...|:.|.:||       :||   |..|
Zfish   265 PTTAAYTNSSDKSQPTPEEGQASQPEPASVPDTAVHSPPYPTPTADNPTTMAEGRAAG---PEHS 326

  Fly   330 LETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEES--SPIKVKKKD 378
            .     :....:|::...|..|.||.:..|.:|...::.|  ||:...::|
Zfish   327 F-----TEPQDATSLPDLNFFSTDSCLQISDALSPSLQSSLDSPVDFSEED 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	76/132 (58%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	49/51 (96%)
hoxb2a	NP_571191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..73		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100		3/19 (16%)
		Antp-type hexapeptide	103..108		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..155		14/48 (29%)
		Homeobox	162..214	CDD:278475	49/51 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..338		31/134 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594717
Domainoid	1	1.000	117	1.000	Domainoid score	I5869
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	1	1.000	-	-		otm26381
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45664
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6877
SonicParanoid	1	1.000	-	-		X2356
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.830