Protein Alignment pb and pitx2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_571050.1
• Gene: pitx2 / 30164
• ZFINID: ZDB-GENE-990714-27
• Length: 314
• Species: Danio rerio
• Alignment Length: 206
• Identity: 62/206 - (30%)
• Similarity: 90/206 - (43%)
• Gaps: 51/206 - (24%)

  Fly   169 KEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAA 233
            |||..|:...:|::..         :....||.||.:|:.||.|||..|..|:|.....|.|||.
Zfish    62 KEKGQSKNEDSNDDPS---------KKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAV 117

  Fly   234 SLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNS-KKSCQGCELPSDDI 297
            ..:|||.:|:|||:|||.|.:::       |.|:        |::...|. .....|...|.||:
Zfish   118 WTNLTEARVRVWFKNRRAKWRKR-------ERNQ--------QAELCKNGFGPQFNGLMQPYDDM 167

  Fly   298 PDSTSNSRGHNNNTPSATNNNPSAGNLTPNSSLET------------GISSNLMGSTTVSASNVI 350
                         .||.|.||.:|..|| ::||.|            .:||..|.|...|.|::.
Zfish   168 -------------YPSYTYNNWAAKGLT-SASLSTKSFPFFNSMNVNPLSSQTMFSPPNSISSMS 218

  Fly   351 SADSSVASSVS 361
            .:.|.|.|:|:
Zfish   219 MSSSMVPSAVT 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	28/55 (51%)
pitx2	NP_571050.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		10/39 (26%)
		Homeodomain	83..139	CDD:459649	28/55 (51%)
		OAR	272..289	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	276..289
		Nuclear localization signal. /evidence=ECO:0000255	282..286