Protein Alignment pb and Pdx1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 288
• Identity: 84/288 - (29%)
• Similarity: 115/288 - (39%)
• Gaps: 71/288 - (24%)

  Fly    61 IGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPV 125
            :|:|..||.|                                  |..|..|..|...||...:|.
  Rat    38 MGRQPPPPPP----------------------------------PQFAGSLGTLEQGSPPDISPY 68

  Fly   126 GSGAI----GGVGVNVNVNVGVGVGY-PVGVVPQ-TPDGMDSVPE-----YPWMKEKKTSRKSSN 179
            ....:    .|..::.::...:|:.: |.|..|. |..|....|.     :||||    |.|:..
  Rat    69 EVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSRVHLPFPWMK----STKAHA 129

  Fly   180 NNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKV 244
            ..:|.........||..  :|.|||||..|||||||||.||||:.||||:|:|..|:||||.:|:
  Rat   130 WKSQWAGGAYAAEPEEN--KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKI 192

  Fly   245 WFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSC---QGCEL--------PSDDIP 298
            ||||||||.|:       :||.|.| .|...........::.|   .|.||        |...:|
  Rat   193 WFQNRRMKWKK-------EEDKKRS-SGTTSGGGGGEEPEQDCAVTSGEELLALPPPPPPGGAVP 249

  Fly   299 DSTSNSRGHNNNTPSATNNNPSAGNLTP 326
            .... :.......||..:.:|...::.|
  Rat   250 SGVP-AAAREGRLPSGLSASPQPSSIAP 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	39/55 (71%)
Pdx1	NP_074043.4	Transactivation domain	13..73		12/68 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		13/76 (17%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeodomain	147..203	CDD:459649	39/55 (71%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		16/85 (19%)