Protein Alignment pb and GBX2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 78/268 - (29%)
• Similarity: 104/268 - (38%)
• Gaps: 66/268 - (24%)

  Fly    34 SLPVGGCGGAGVVGGVGGVGVSVGQ-PGIGQQGVPPVPSVLMVNKMTP-------NCDKRSADTA 90
            |||.|.|  :.:..|:......:.. || |....|.........|..|       |.||..|..|
Human    85 SLPTGFC--SSLAQGMALTSTLMATLPG-GFSASPQHQEAAAARKFAPQPLPGGGNFDKAEALQA 146

  Fly    91 YWMTASEG-GFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQ 154
               .|.:| ||:..:.|:..|         .....|.:..:|.|.         |.|.....|..
Human   147 ---DAEDGKGFLAKEGSLLAF---------SAAETVQASLVGAVR---------GQGKDESKVED 190

  Fly   155 TPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDN--------------SITEFVPENGLP------- 198
            .|.|          ||:..|.:|..:.:..||              ::.|..|.:|..
Human   191 DPKG----------KEESFSLESDVDYSSDDNLTGQAAHKEEDPGHALEETPPSSGAAGSTTSTG 245

  Fly   199 --RRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKT 261
              ||.|||:|:.||||||||||..|||....|.:||.:|.|:|.|||:||||||.|.||......
Human   246 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNA 310

  Fly   262 DDEDNKDS 269
            :.:..:.|
Human   311 NSKTGEPS 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	35/55 (64%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		16/90 (18%)
		Homeodomain	248..304	CDD:459649	35/55 (64%)