DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and GBX2

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001476.2	Gene:	GBX2 / 2637	HGNCID:	4186	Length:	348	Species:	Homo sapiens

Alignment Length:	268	Identity:	78/268 - (29%)
Similarity:	104/268 - (38%)	Gaps:	66/268 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SLPVGGCGGAGVVGGVGGVGVSVGQ-PGIGQQGVPPVPSVLMVNKMTP-------NCDKRSADTA 90
            |||.|.|  :.:..|:......:.. || |....|.........|..|       |.||..|..|
Human    85 SLPTGFC--SSLAQGMALTSTLMATLPG-GFSASPQHQEAAAARKFAPQPLPGGGNFDKAEALQA 146

  Fly    91 YWMTASEG-GFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQ 154
               .|.:| ||:..:.|:..|         .....|.:..:|.|.         |.|.....|..
Human   147 ---DAEDGKGFLAKEGSLLAF---------SAAETVQASLVGAVR---------GQGKDESKVED 190

  Fly   155 TPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDN--------------SITEFVPENGLP------- 198
            .|.|          ||:..|.:|..:.:..||              ::.|..|.:|..
Human   191 DPKG----------KEESFSLESDVDYSSDDNLTGQAAHKEEDPGHALEETPPSSGAAGSTTSTG 245

  Fly   199 --RRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKT 261
              ||.|||:|:.||||||||||..|||....|.:||.:|.|:|.|||:||||||.|.||......
Human   246 KNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNA 310

  Fly   262 DDEDNKDS 269
            :.:..:.|
Human   311 NSKTGEPS 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	47/125 (38%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	33/51 (65%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..139		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		16/90 (18%)
		Homeobox	250..303	CDD:306543	33/52 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810