DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and GBX1

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001092304.1	Gene:	GBX1 / 2636	HGNCID:	4185	Length:	363	Species:	Homo sapiens

Alignment Length:	234	Identity:	67/234 - (28%)
Similarity:	91/234 - (38%)	Gaps:	74/234 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GGAGVVGGVGGVGVSVGQPGIGQQGVPP-------VPSVLMVNKMTPNCDKR----SADTAYWMT 94
            ||....||:....:...:..:.:...||       .||:....|:..:.:::    :.|.|....
Human   140 GGRRPEGGLEADELLPAREKVAEPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEASAGDPAGSEQ 204

  Fly    95 ASEG--------GFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGV 151
            ..||        ||::|.......|  |.|: ||:...:|:||..|..|.      .||..|
Human   205 EEEGSGGDSEDDGFLDSSAGGPGAL--LGPK-PKLKGSLGTGAEEGAPVT------AGVTAP--- 257

  Fly   152 VPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKE 216
                                                       .|..||.|||:|:.||||||||
Human   258 -------------------------------------------GGKSRRRRTAFTSEQLLELEKE 279

  Fly   217 FHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKR 255
            ||..|||....|.:||.:|.|:|.|||:||||||.|.||
Human   280 FHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKR 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	38/88 (43%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	33/51 (65%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..265		32/179 (18%)
		Homeobox	264..317	CDD:306543	33/52 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810