DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and GSX1

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_663632.1	Gene:	GSX1 / 219409	HGNCID:	20374	Length:	264	Species:	Homo sapiens

Alignment Length:	270	Identity:	80/270 - (29%)
Similarity:	118/270 - (43%)	Gaps:	67/270 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QGVPP------VPSVLMVNKMTPN-CDKRSAD----TAYWMTASEGGFINSQPSMAEFLNHLSPE 117
            :|.||      ||....::.::|. |..|.|.    ....:|||:   ::..|. ...|..|...
Human    22 EGSPPPLFPYAVPPPHALHGLSPGACHARKAGLLCVCPLCVTASQ---LHGPPG-PPALPLLKAS 82

  Fly   118 SPKIGTPVGSGAIG--GVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKK---TSRKS 177
            .|..|:......:|  ...|:..|..|.........:.||        .||....::   .|..|
Human    83 FPPFGSQYCHAPLGRQHSAVSPGVAHGPAAAAAAAALYQT--------SYPLPDPRQFHCISVDS 139

  Fly   178 SNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQV 242
            |:|.          :|.:   :|:|||:|:|||||||:||..|.||.|.||||||..|:|:|:||
Human   140 SSNQ----------LPSS---KRMRTAFTSTQLLELEREFASNMYLSRLRRIEIATYLNLSEKQV 191

  Fly   243 KVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNS---KKSCQGCELPS---------- 294
            |:||||||:|||::.             ||.:.:......:   ..:.|||:..|
Human   192 KIWFQNRRVKHKKEG-------------KGSNHRGGGGGGAGGGGSAPQGCKCASLSSAKCSEDD 243

  Fly   295 DDIPDSTSNS 304
            |::|.|.|:|
Human   244 DELPMSPSSS 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	46/108 (43%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	36/51 (71%)
GSX1	NP_663632.1	SNAG domain. /evidence=ECO:0000250	1..20
		Homeobox	151..204	CDD:395001	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..264		14/66 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810