Protein Alignment pb and Tlx2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_033418.1
• Gene: Tlx2 / 21909
• MGIID: 1350935
• Length: 284
• Species: Mus musculus
• Alignment Length: 170
• Identity: 52/170 - (30%)
• Similarity: 78/170 - (45%)
• Gaps: 21/170 - (12%)

  Fly   115 SPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTP--------DGMDSVPEYPWM--- 168
            :|.......|.|||...|..:.|..:..:.|..|.|..|..|        .|:..: .:|||
Mouse    61 APAGSLASLPRGSGVGPGGVIRVPAHRPLPVPPPSGAAPAVPGPSGLGGAGGLAGL-TFPWMDSG 124

  Fly   169 ----KEKKTSRKS--SNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPR 227
                |::.|:..|  |.....|........|:...|   ||:::.:|:||||:.|...|||....
Mouse   125 RRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKP---RTSFSRSQVLELERRFLRQKYLASAE 186

  Fly   228 RIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNK 267
            |..:|.:|.:|:.|||.||||||.|.:|||..:.:.|.::
Mouse   187 RAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHR 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	25/55 (45%)
Tlx2	NP_033418.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..104		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..166		6/28 (21%)
		Homeodomain	158..214	CDD:459649	26/58 (45%)