Protein Alignment pb and Alx1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001408403.1
• Gene: Alx1 / 216285
• MGIID: 104621
• Length: 377
• Species: Mus musculus
• Alignment Length: 380
• Identity: 84/380 - (22%)
• Similarity: 125/380 - (32%)
• Gaps: 128/380 - (33%)

  Fly   158 GMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLP---------------------RRL 201
            |:..|...|...|  .:|...|.||      ....|..|:|                     ||.
Mouse    79 GITKVEGQPLHTE--LNRAMDNCNN------LRMSPVKGMPEKSELDELGDKCDSNVSSSKKRRH 135

  Fly   202 RTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMK-HKRQTLSKTDDED 265
            ||.:|:.||.||||.|....|.....|.::|...:|||.:|:|||||||.| .||:..
Mouse   136 RTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERY------- 193

  Fly   266 NKDSLKGDDDQSDSNSNSKKSCQGCELP-SDDIPDSTSNSRGHNNNTPSATNNNPSAGNLTPNSS 329
                  |...|:.|:..:.....  .|| :|..|.               ..||..|||
Mouse   194 ------GQIQQAKSHFAATYDIS--VLPRTDSYPQ---------------IQNNLWAGN------ 229

  Fly   330 LETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEE-SSPIKVKKKDDGQVIKKEAVSTSSK 393
                                 ::..||.:|..|..|... .:|.....:.|
Mouse   230 ---------------------ASGGSVVTSCMLPRDASSCMTPYSHSPRTD-------------- 259

  Fly   394 ASPFGYEN-----STPSLVSFRRDSDASAVGNAPTSKAVGKKRFQSAANAIATPTPLSDSNSGNG 453
            :|..|:.|     |...|.:|..||..:...|....:.  |..|:..:::||.....:..::.|.
Mouse   260 SSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFET--KPEFERRSSSIAVLRMKAKEHTANI 322

  Fly   454 SGGG----------------PAGGYFPGYYPSPKQQQQVQQQQLHPQQQQLPQQQ 492
            |...                |||  |...:|||.....:..::...:.|:||:::
Mouse   323 SWAMFDITVHSLLPGQCLHIPAG--FLLSHPSPPGLMNISARKSEKEAQELPKEK 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	27/56 (48%)
Alx1	NP_001408403.1	Homeodomain	133..189	CDD:459649	27/55 (49%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		34/206 (17%)
		OAR	302..320	CDD:461067	2/17 (12%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		2/12 (17%)