Protein Alignment pb and Nkx1-2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_033149.1
• Gene: Nkx1-2 / 20231
• MGIID: 104806
• Length: 305
• Species: Mus musculus
• Alignment Length: 327
• Identity: 74/327 - (22%)
• Similarity: 109/327 - (33%)
• Gaps: 121/327 - (37%)

  Fly    27 QVQTGQTSL---PVGGCGGAGVVGGVGGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCDKRSAD 88
            :|:.||.:.   |:|.......||.    |:..|.|..|.:..                ::..|:
Mouse    52 EVEAGQDACSGNPIGSQETPDAVGR----GIDPGSPVEGSEAE----------------EEEEAE 96

  Fly    89 TA-------YWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVG 146
            .|       .|....||                |||:..:.
Mouse    97 DAGRAHQPERWQGVHEG----------------SPEARAVA------------------------ 121

  Fly   147 YPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLPRRLRTAYTNTQLL 211
              ||......:|:.:.|..|.....:..|..|:               ...|||.|||:|..||:
Mouse   122 --VGTEESGAEGLPASPGSPGSPRPRRRRAESS---------------CAKPRRARTAFTYEQLV 169

  Fly   212 ELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQ 276
            .||.:|...:||....|:.:|.||.|||.|||:||||||.|.|:|
Mouse   170 ALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQ-------------------- 214

  Fly   277 SDSNSNSKKSCQ-GCELPSDDIPDSTSNSRGHNNNTPSATNNNPS---AGNLTPNSSLETGISSN 337
               |..:..:.| |...|....|.:.:...|      |||.::|.   .|.| |..:..|..::|
Mouse   215 ---NPGADGAVQAGGGAPQPGTPGAVAGGGG------SATGSSPGPPVPGAL-PYQTFPTYPATN 269

  Fly   338 LM 339
            ::
Mouse   270 VL 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	30/55 (55%)
Nkx1-2	NP_033149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..158		27/182 (15%)
		Homeodomain	157..213	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..257		14/75 (19%)