DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and Hoxd3

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	380	Identity:	105/380 - (27%)
Similarity:	145/380 - (38%)	Gaps:	91/380 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSLDT--TSMGTQIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGIGQQGVPP 68
            :|||:  .|....|:|.:||.....:..:.:   |.|...|.....||.|.: ..||:..:..||
Mouse    57 NSLDSDYPSSACSIQSSAPLRAPAHKGAELN---GSCMRPGTGNSQGGGGGN-QPPGLNSEQQPP 117

  Fly    69 VPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGV 133
            .|                                             |..|....|..|....|.
Mouse   118 QP---------------------------------------------PPPPPPTLPPSSPTNPGS 137

  Fly   134 GVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGLP 198
            ||......|       |:...:.....|...:|||||.:.:.|..|:......:..:..|.....
Mouse   138 GVPAKKTKG-------GLSASSSSSTISKQIFPWMKESRQNSKQKNSCATSGENCEDKSPPGPAS 195

  Fly   199 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDD 263
            :|:|||||:.||:|||||||||:|||||||:|:|..|:|||||:|:||||||||:|:       |
Mouse   196 KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKK-------D 253

  Fly   264 EDNKDSLKGDDDQSDSNSNSKKSCQG-----CELP-----SDDIPDSTSNSRGHNNNTPSATNNN 318
            :..|..|.....||...|.......|     .:||     :.|.|...:.::...|....|....
Mouse   254 QKAKGILHSPAGQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTA 318

  Fly   319 P-----------SAGNLTPNSSLETG---ISSNLMGSTTVSASNVISADSSVASS 359
            |           .|....|:.....|   .|:||.||......|.:  ||...:|
Mouse   319 PLSSCLPQQKRYPAPEFEPHPMASNGGGFASANLQGSPVYVGGNFV--DSMAPTS 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	51/105 (49%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	40/51 (78%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		37/196 (19%)
		Antp-type hexapeptide	161..166		2/4 (50%)
		Homeobox	199..251	CDD:278475	40/51 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		4/21 (19%)
		DUF4074	370..431	CDD:290032	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810