DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pb and Hoxb3

DIOPT Version :9

Sequence 1:	NP_476669.3	Gene:	pb / 40826	FlyBaseID:	FBgn0051481	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus

Alignment Length:	359	Identity:	104/359 - (28%)
Similarity:	144/359 - (40%)	Gaps:	79/359 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GGVGVSVGQPGIGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQP-SMAEFLN- 112
            ||.....|..|.|..| ||.|.......:..:. :|||       .|.....|:.| :.::.||
Mouse    16 GGYSSYPGSNGFGYDG-PPQPPFQAATHLEGDY-QRSA-------CSLQSLGNAAPHAKSKELNG 71

  Fly   113 -----HLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSV---PEYPWMK 169
                 .|:||  .:..|.||........:...|...|.|......|:...|.:|.   ..:||||
Mouse    72 SCMRPGLAPE--PLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMK 134

  Fly   170 EKKTSRKSSNNN--------------------------------NQGDNSITEFVPENGLPRRLR 202
            |.:.:.|..|::                                ..||.|    .|.:...:|.|
Mouse   135 ESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKS----PPGSAASKRAR 195

  Fly   203 TAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLSKTDDEDNK 267
            ||||:.||:|||||||||:|||||||:|:|..|:|:|||:|:||||||||:|:...:|     ..
Mouse   196 TAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAK-----GL 255

  Fly   268 DSLKGDDDQSDSNSNSKKSCQG------CELPSDDIPDSTSNSRGHNNNTPSATNNNPSAGNL-- 324
            .|..|....:.|.....:|..|      ...||.|.|...:..:||.|.....:|..|.....
Mouse   256 ASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGA 320

  Fly   325 ------TPNSSLETGI---SSNLMGSTTVSASNV 349
                  ||.|..|..:   :....|:.|:..|.|
Mouse   321 PQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPV 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	COG5576	168..274	CDD:227863	53/137 (39%)
pb	NP_476669.3	Homeobox	202..254	CDD:278475	39/51 (76%)
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		13/62 (21%)
		Antp-type hexapeptide	129..134		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		7/62 (11%)
		Homeobox	195..248	CDD:365835	39/52 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		5/31 (16%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810