Protein Alignment pb and nkx1-1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: XP_002936812.1
• Gene: nkx1-1 / 100493120
• XenbaseID: XB-GENE-488879
• Length: 408
• Species: Xenopus tropicalis
• Alignment Length: 429
• Identity: 104/429 - (24%)
• Similarity: 140/429 - (32%)
• Gaps: 146/429 - (34%)

  Fly    32 QTSLPVGGCGGAGVVGGV-----GGVGVSVGQ--------PGIG----QQGVPP----------- 68
            |..:|:||...||||..|     |.:..|.|:        |..|    :||..|
 Frog     9 QLDMPIGGAQAAGVVEAVTCGLHGEMMDSHGEQRLTASDLPAYGCPRDRQGDHPNCNAPAGPESL 73

  Fly    69 --------------VPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAE---------- 109
                          |..:|..||.  |..:|....||   ...|.:|......||
 Frog    74 GAAPLAVHRTTSFSVLDILDPNKF--NSKQRHCSGAY---KPPGDYILRGEEKAEGPDIATGQKA 133

  Fly   110 FL-------------------NHLSPE-------SPKIG-----------------------TPV 125
            ||                   .|.:.|       ||..|                       ||.
 Frog   134 FLEEYESCKKSTEVIKEEGLYQHSATEDCQTQEFSPSPGSDLEEEEDEEEDEEICSEESSNSTPS 198

  Fly   126 G-----SGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGD 185
            |     .||..|.|.:     .:..|.|.|...|.|.|.:...:   .:..|..||.:.:::
 Frog   199 GLAERDPGAGNGQGED-----ALNTGAPAGSNQQQPTGKNQQQQ---NQHGKPKRKRTGSDS--- 252

  Fly   186 NSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRR 250
                    ::|.|||.|||:|..||:.||.:|...:||....|:.:|.||.|||.|||:||||||
 Frog   253 --------KSGKPRRARTAFTYEQLVALENKFKSTRYLSVCERLNLALSLSLTETQVKIWFQNRR 309

  Fly   251 MKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRGHNNNTPSAT 315
            .|.|:|...            .|.......|.......|..|.....|.|.|...|:    |.|.
 Frog   310 TKWKKQNPG------------ADTSAPTGGSGHGGGGSGSVLGGGLSPLSHSPPMGN----PMAL 358

  Fly   316 NNNPSAGNLTPNSSLETGISSNLMGSTTVSASNVISADS 354
            :.:....:..|...:.|.....|.|...|.:..|:|:.|
 Frog   359 HGHHGYPSHAPGGLMCTAQLPFLPGPAAVLSPFVLSSQS 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	30/55 (55%)
nkx1-1	XP_002936812.1	Homeodomain	258..314	CDD:459649	30/55 (55%)