DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Edg84A and Cntrl

DIOPT Version :9

Sequence 1:	NP_524247.1	Gene:	Edg84A / 40818	FlyBaseID:	FBgn0000552	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	NP_001366203.1	Gene:	Cntrl / 26920	MGIID:	1889576	Length:	2334	Species:	Mus musculus

Alignment Length:	193	Identity:	42/193 - (21%)
Similarity:	69/193 - (35%)	Gaps:	53/193 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PLPA---KSSGSEDTYDS--HPQYSFNYDVQDPETGDVKSQSESRDG----------------DV 62
            |.|:   .|..|:.|.||  ..:|:.:..::.|:.|    |.|.:|.                ..
Mouse  1150 PAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPG----QQEEKDSSGPLPASGYWVYSPIRST 1210

  Fly    63 VHGQYSV-NDADGYRRTVDYTADDVRGFNAVVRRE------PLSSAAVVVKPQATAVVPKVQL-K 119
            :|..:|. .|||        :..|.:..:.:..:|      |.......|.|..:.|...|.| .
Mouse  1211 LHKSFSKREDAD--------SGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYA 1267

  Fly   120 PLKKLP-ALKPLSQASAVVHRSFAPVVHHAPVTHVVHHAAPAHSFVSHHVPVLKTTVHHAHHP 181
            |...|| :..||:..:.|    :.|....||:.    :..|..:|.   ||::...|.|.:.|
Mouse  1268 PSPPLPNSSHPLTPGTVV----YGPPPAGAPII----YGPPPANFA---VPLVPAGVQHCNIP 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edg84A	NP_524247.1	Chitin_bind_4	37..89	CDD:278791	12/68 (18%)
Cntrl	NP_001366203.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		PPP1R42	89..261	CDD:411060
		leucine-rich repeat	100..119	CDD:275378
		LRR 1	126..147
		leucine-rich repeat	127..148	CDD:275380
		LRR 2	148..169
		leucine-rich repeat	149..170	CDD:275380
		LRR 3	170..191
		leucine-rich repeat	171..194	CDD:275380
		LRR 4	194..215
		leucine-rich repeat	195..219	CDD:275380
		leucine-rich repeat	220..246	CDD:275380
		Smc	<270..602	CDD:224117
		Smc	440..>1134	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	751..771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1154..1198		11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1245		6/39 (15%)
		Drf_FH1	<1239..1310	CDD:399386	19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1360
		SMC_prok_B	1407..2216	CDD:274008
		Required for centrosome localization. /evidence=ECO:0000250	1951..2121
		Sufficient for interaction with HOOK2. /evidence=ECO:0000250	1988..2334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2291..2334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910