Protein Alignment lab and LBX2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001269359.1
• Gene: LBX2 / 85474
• HGNCID: 15525
• Length: 198
• Species: Homo sapiens
• Alignment Length: 235
• Identity: 63/235 - (26%)
• Similarity: 86/235 - (36%)
• Gaps: 77/235 - (32%)

  Fly   399 RNVPK-PQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQN 462
            |.||: |.||:||.|                           |.||.      || :..:..:.:
Human    23 RMVPRAPSAPQLPES---------------------------GPGPT------SP-LCALEELTS 53

  Fly   463 SLIMANSAAA----AGSAHPNGMGVG-LGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHF 522
            .......|.|    .|.|.|:.:|.| .|            ......||.||.:|:.|||:.|.|
Human    54 KTFRGLDARALQPSEGRAGPDALGPGPFG------------RKRRKSRTAFTAQQVLELERRFVF 106

  Fly   523 NRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQ 587
            .:||..:.|..:|..|.|...||..||||||.|.|:.|:|  :.||:.:..:.|
Human   107 QKYLAPSERDGLATRLGLANAQVVTWFQNRRAKLKRDVEE--MRADVASLRALS----------- 158

  Fly   588 PQPPELQLKSQGSDLGGNELATGAPSTPTTAMTLTAPTSK 627
               ||:        |....|..|||. |...:....|.|:
Human   159 ---PEV--------LCSLALPEGAPD-PGLCLGPAGPDSR 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	25/52 (48%)
LBX2	NP_001269359.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		13/55 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..89		7/37 (19%)
		Homeodomain	86..142	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..198		3/15 (20%)