Protein Alignment lab and NKX6-2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 246
• Identity: 62/246 - (25%)
• Similarity: 95/246 - (38%)
• Gaps: 66/246 - (26%)

  Fly   403 KPQAPKLPASGIASMHD----------YQMNGQLDM---CRGGGG---------GGSGVGNGPVG 445
            :|.|..|.::.:|::|:          |.:.|....   ..||.|         |.|.:...|||
Human     5 RPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGISDILGRPVG 69

  Fly   446 VGG----NGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMG----------VGLGSGSGLSSCSL 496
            ..|    .|.|.:.|:.|  ::.:....|||....:|..:.          .|:..|:......|
Human    70 AAGGGLLGGLPRLNGLAS--SAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGAPWRDPRL 132

  Fly   497 SSNTNNSG-----------RTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQ 550
            :......|           |..|:.:|:..|||.|...:||....|..:|.:|.:.|:|||:|||
Human   133 AGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQ 197

  Fly   551 NRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQPQPPELQLKSQGSD 601
            |||.|.:||             |:..:.|.|..|....:    :||..|||
Human   198 NRRTKWRKR-------------HAVEMASAKKKQDSDAE----KLKVGGSD 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	23/52 (44%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		8/52 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		3/22 (14%)
		Homeodomain	147..205	CDD:459649	23/57 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		8/26 (31%)