DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and Hoxa5

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_077365.1	Gene:	Hoxa5 / 79241	RGDID:	620609	Length:	381	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	114/493 - (23%)
Similarity:	158/493 - (32%)	Gaps:	166/493 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PTSSHQVVQQHQQQQQAQQQQLYPHS---HLFSPSAAEYGITTSTTTGNPGTPLHP-SSHSP-AD 150
            ||...:.|...:........:|:|..   |.|:....:.|.||       |...|. .|.:| ..
  Rat    12 PTERRRRVAGTRPGSARHPSRLHPTPPLLHEFTSRGHQAGFTT-------GQQKHVIRSRTPYLG 69

  Fly   151 SYYESDSVHSYYATAAVATVAPPSNSSPITAANASATSNTQQQQQQAAIISSENGMMYTNLDC-M 214
            :|...:.||....:.....:...:..:..||::.|:|.           |..:....:.|..| .
  Rat    70 AYVGGNRVHVPVISIIHHKLCKGAIDAQTTASHKSSTH-----------IKKQMSSYFVNSFCGR 123

  Fly   215 YPTAQAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYALDA 279
            ||.. ....:|.|.                      |...:.:|...|...|..::   .|..:.
  Rat   124 YPNG-PDYQLHNYG----------------------DHSSVSEQFRDSASMHSGRY---GYGYNG 162

  Fly   280 MD-SLGMHAHMHHGLPHGHLGNLANN-----------PHQQQPQVQQQQQQPHQQPQHPQNQSPA 332
            || |:|.....|.|     .|..|.:           |...||........|...|......||.
  Rat   163 MDLSVGRSGSGHFG-----SGERARSYAAGASAAPAEPRYSQPATSTHSPPPDPLPCSAVAPSPG 222

  Fly   333 AHQQHH--QNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIP----- 390
            : ..||  :||:..:.|.:.......||......::::|...|..:|.|:.:.:..|..|
  Rat   223 S-DSHHGGKNSLGNSSGASANAGSTHISSREGVGTASAAEEDAPASSEQAGAQSEPSPAPPAQPQ 286

  Fly   391 TYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIG 455
            .|.||:           ||..|     ||                                 .||
  Rat   287 IYPWMR-----------KLHIS-----HD---------------------------------NIG 302

  Fly   456 GVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEF 520
            |                     |.|                     ...||.:|..|..||||||
  Rat   303 G---------------------PEG---------------------KRARTAYTRYQTLELEKEF 325

  Fly   521 HFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKK 558
            ||||||||.||||||:.|.|:|.|:||||||||||.||
  Rat   326 HFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKK 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	38/51 (75%)
Hoxa5	NP_077365.1	Homeobox	310..363	CDD:365835	38/52 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910