DRSC/TRiP Functional Genomics Resources

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Protein Alignment lab and Nkx6-1

DIOPT Version :10

Sequence 1:NP_476613.1 Gene:lab / 40817 FlyBaseID:FBgn0002522 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_113925.1 Gene:Nkx6-1 / 65193 RGDID:69318 Length:365 Species:Rattus norvegicus


Alignment Length:445 Identity:97/445 - (21%)
Similarity:151/445 - (33%) Gaps:131/445 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 QQQAAIISSENGMMYTNLDCMYPTAQAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQ 258
            :|.|.::||      ..|..::..|:.:.|::              .|:|.|   |....|....
  Rat    11 RQSAFLLSS------PPLAALHSMAEMKTPLY--------------PAAYPP---LPTGPPSSSS 52

  Fly   259 ATQSQMWHHQQHLAGSYALDAMDSLGMHAHMHHGL---PHGHLGNLANNPHQQQPQVQQQQQQPH 320
            ::.|               .:..|..:.||...||   ..|.|.:|.:.|.|.....      ||
  Rat    53 SSSS---------------SSSPSPPLGAHNPGGLKPPAAGGLSSLGSPPQQLSAAT------PH 96

  Fly   321 ------QQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQ 379
                  .:|..|.....|.      .|.||:|..:...     |..|:||:|.:|:..|..|:..
  Rat    97 GINDILSRPSMPVASGAAL------PSASPSGSSSSSS-----SSASATSASAAAAAAAAAAAAA 150

  Fly   380 SKSP-NHSSSIPTYKWMQLKRNVPKPQAPKL----PASGIASMHDY-----QMNGQLDMCRGGGG 434
            :.|| ...:.:|.:..:.     |.|..|.|    .|:.:|::..|     ::.|:..:.     
  Rat   151 ASSPAGLLAGLPRFSSLS-----PPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIF----- 205

  Fly   435 GGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSN 499
             ..||...|..                      ..|..|.:.|         .||.|..   ...
  Rat   206 -WPGVMQSPPW----------------------RDARLACTPH---------QGSILLD---KDG 235

  Fly   500 TNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGL 564
            .....|..|:.:|:..|||.|...:||....|..:|.:|.:.|:|||:||||||.|.:|:....:
  Rat   236 KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEM 300

  Fly   565 IPA----DILTQH--STSVISEKPPQQQQPQPPE------LQLKSQGSDLGGNEL 607
            ..|    |..|:.  .||...|......:|..|.      .||..:....||:.|
  Rat   301 ATAKKKQDSETERLKGTSENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLL 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
labNP_476613.1 Homeodomain 505..558 CDD:459649 23/52 (44%)
Nkx6-1NP_113925.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..136 28/149 (19%)
Repressor domain. /evidence=ECO:0000250 102..269 45/222 (20%)
Homeodomain 236..294 CDD:459649 23/57 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 13/61 (21%)
Involved in DNA-binding. /evidence=ECO:0000250 307..365 12/49 (24%)

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