DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and hoxa4a

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_571610.1	Gene:	hoxa4a / 58050	ZFINID:	ZDB-GENE-000823-4	Length:	245	Species:	Danio rerio

Alignment Length:	315	Identity:	80/315 - (25%)
Similarity:	103/315 - (32%)	Gaps:	133/315 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 GLPHGHLGNLANNPHQQQP---------QVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGG 347
            |.||....:...:.:|:|.         .:.....:.|.|||                |||.|.|
Zfish    43 GFPHHEEASYPRSNYQEQSYDYGNVSTNDLNDFSDRHHAQPQ----------------SVSQNHG 91

  Fly   348 MNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPAS 412
            ........|   ||..:...|..:.|.|.|.:||.|      ..|.||:
Zfish    92 PRLTTESCV---GSDGNKDCSLVSDALPGSQKSKEP------VVYPWMK---------------- 131

  Fly   413 GIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAH 477
                                                                          ..|
Zfish   132 --------------------------------------------------------------KVH 134

  Fly   478 PNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNE 542
            .|.:           :.|.|.......||.:|.:|..||||||||||||||.||:|||:|:.|:|
Zfish   135 VNTV-----------TASYSGGVPKRSRTAYTRQQALELEKEFHFNRYLTRRRRVEIAHTMCLSE 188

  Fly   543 TQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSV----ISEKPPQQQQ---PQP 590
            .||||||||||||.||..|   :|...:...|::.    :.....||||   |.|
Zfish   189 RQVKIWFQNRRMKWKKDHK---LPNTKIRSSSSAPSNHHVKTDATQQQQTLLPTP 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	38/51 (75%)
hoxa4a	NP_571610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..99		14/71 (20%)
		Antp-type hexapeptide	126..131		2/4 (50%)
		Homeobox	150..203	CDD:278475	38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..245		9/39 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000