Protein Alignment lab and nkx6.2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001129256.1
• Gene: nkx6.2 / 565782
• ZFINID: ZDB-GENE-070626-1
• Length: 278
• Species: Danio rerio
• Alignment Length: 319
• Identity: 71/319 - (22%)
• Similarity: 116/319 - (36%)
• Gaps: 89/319 - (27%)

  Fly   356 VISPGSSTSSSTSA-SNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPASGIASMHD 419
            :::.|...|:..|| ..|:.|.:.........:|:..|.       :..|...|.|:.|
Zfish     1 MLAVGQMDSNRQSAFVLGSTPLAALHNMTEMKTSLFPYA-------LQSPAGFKAPSLG------ 52

  Fly   420 YQMNGQLDMCRGGGGGGSGVGNGPVGVGG---NGSPGIGGVLSVQNSLIMANSAA-----AAGSA 476
             .:|.|:.:  |...|.|.:...|:...|   :|.|.|.|         :|.||.     ||.|.
Zfish    53 -NLNSQIPL--GTPHGISDILGRPITTAGQLLSGFPRING---------LATSAGMYFNPAAVSR 105

  Fly   477 HPNGM----------GVGLGSGSGLSS----CSLSSN-------TNNSGRTNFTNKQLTELEKEF 520
            :|..:          ..|:..||....    |:..:|       .....|..|:.:|:..|||.|
Zfish   106 YPKPLTELPGRAPIFWPGMMQGSPWRDPRVPCAAQANMMLDKDGKKKHSRPTFSGQQIFALEKTF 170

  Fly   521 HFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQ 585
            ...:||....|..:|.:|.:.|:|||:||||||.|.:||             |:..:.:.|....
Zfish   171 EQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKR-------------HAAEMATAKKKHD 222

  Fly   586 QQPQPPELQLKSQGSDLGGNELATGAPSTP---------------TTAMTLTAPTSKQS 629
            .:.:    ::|....:...:|.  ..|..|               |:.::|.:|.|..|
Zfish   223 SETE----KMKESSDNDEDDEY--NKPLDPNSDDEKITRLLKKHKTSNLSLLSPCSNSS 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	23/52 (44%)
nkx6.2	NP_001129256.1	Homeodomain	150..208	CDD:459649	23/57 (40%)