Protein Alignment lab and NKX3-1

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_006158.2
• Gene: NKX3-1 / 4824
• HGNCID: 7838
• Length: 234
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 55/207 - (26%)
• Similarity: 75/207 - (36%)
• Gaps: 76/207 - (36%)

  Fly   401 VPKPQ---------APKLPASGIAS--MHDYQMNGQLDMCRGGG-------------------GG 435
            ||:|:         ||..|:..:.|  :.|...:|..   |.||                   ||
Human     4 VPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQ---RQGGRTSSQRQRDPEPEPEPEPEGG 65

  Fly   436 GS--GVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSS 498
            .|  |..|..:..|...:|               ..|.......|..   .|||       .|..
Human    66 RSRAGAQNDQLSTGPRAAP---------------EEAETLAETEPER---HLGS-------YLLD 105

  Fly   499 NTNNSG----------------RTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKI 547
            :.|.||                |..|::.|:.|||::|...:||:...|..:|..|:|.||||||
Human   106 SENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKI 170

  Fly   548 WFQNRRMKQKKR 559
            ||||||.|.|::
Human   171 WFQNRRYKTKRK 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	26/52 (50%)
NKX3-1	NP_006158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		29/154 (19%)
		Homeodomain	125..181	CDD:459649	26/55 (47%)