Protein Alignment lab and zfh2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Alignment Length: 693
• Identity: 138/693 - (19%)
• Similarity: 218/693 - (31%)
• Gaps: 224/693 - (32%)

  Fly     3 DVSSMYGNHPHHHHPHANAYDGYSTTTASAANASSYFAPQQHQPHLQ-----LQQQQQHQHLQQP 62
            |||      |.....|.|....:.:.|..:.::      |.||.||.     |:|||.
  Fly  1606 DVS------PIELETHLNKETRHLSPTPMSLDS------QSHQKHLATFAALLKQQQC------- 1651

  Fly    63 QQHLTYNGYESSSPGNYYPQQQAQLT---PPPTSSHQVVQQHQQQ------------QQAQQQQL 112
                      :|..|..:|:..:..|   ||.....|.:|..||.            .......:
  Fly  1652 ----------NSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVDMLNI 1706

  Fly   113 YPHSHLFS-----------------------PSAAEYGITTSTTTGNPGTPLHPSSHSPADSYYE 154
            ....||.|                       |||....|||||.|...|.         .|::..
  Fly  1707 MQFHHLMSLNFMNLAPPLVFGANAAGNAVSGPSALNNSITTSTATSASGL---------GDTHLT 1762

  Fly   155 SDSVHSYYATAAVATVAPPSNSSPITAANASATSN---TQQQQQQAAIISSENGMMYTNLD---- 212
            | .|.|....:..||..||.     |..||:|.|.   :.|::.:..|...:..::..:.|
  Fly  1763 S-GVSSIPVDSGKATAVPPQ-----TQLNANANSQQLASNQKRARTRITDDQLKILRAHFDINNS 1821

  Fly   213 -----CMYPTAQAQAPV----HGYAGQI-----------------------EEKYAAVLHASYAP 245
                 .|..:.:|..|:    |.:...:                       .|:|.....|...|
  Fly  1822 PSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTP 1886

  Fly   246 GMVLED------QDPM-----------------MQQATQSQMWHHQQHLAGSYALDAM------- 280
               |.|      ..||                 .:.||...:...:.:.:|.....|.
  Fly  1887 ---LNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVLAAGKANASGPVTFSATVPVSTPL 1948

  Fly   281 -------DSLGMHAHMHHGLPHGHLGNLAN-NPHQQQPQVQQQQQQ--------PHQQPQHPQNQ 329
                   .|..:..::.:.:..|.||:... .|:....|::.:.|.        .:|..||
  Fly  1949 SRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIGATDFAYQTKQH---- 2009

  Fly   330 SPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPAST---QSKSPNHSSSIPT 391
            |..:..:..|:.|.|.......|........|..:.|:.|||.......   ::||.:.||.:
  Fly  2010 SSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDV-- 2072

  Fly   392 YKWMQLKRNVPKPQAPKLPASG--IASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSP-- 452
                     :.:|.:|...|:|  ..||:|. :|.||:                 .:|.|..|
  Fly  2073 ---------LSRPPSPNSGAAGNVYGSMNDL-LNQQLE-----------------NMGSNMGPPK 2110

  Fly   453 --GIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTE 515
              .|.|....:|...|..|.:.:.....|       |.:..||.|.:|....:.||.||:.|:..
  Fly  2111 KMQIVGKTFEKNVAPMVTSGSVSTQFESN-------SSNSSSSSSSTSGGKRANRTRFTDYQIKV 2168

  Fly   516 LEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKK 558
            |::.|..|.|...:....::..|.|:...:.:||||.|.||:|
  Fly  2169 LQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRK 2211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	18/52 (35%)
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	616..633	CDD:275368
		C2H2 Zn finger	1515..1542	CDD:275371
		C2H2 Zn finger	1543..1564	CDD:275371
		Homeodomain	1798..1857	CDD:459649	6/58 (10%)
		Homeodomain	2155..2211	CDD:459649	18/55 (33%)
		Homeodomain	2761..2817	CDD:459649