Protein Alignment lab and en

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 140/657 - (21%)
• Similarity: 232/657 - (35%)
• Gaps: 212/657 - (32%)

  Fly    40 APQQHQPHLQLQQQQQHQHLQQPQQHLTYNGYESSSPGNYYPQQQAQLTPPPTSSHQVVQQHQQQ 104
            :||.....:.||.|..| |.||.||                 |||.|:        |.:.|.||.
  Fly     8 SPQSAPSPITLQMQHLH-HQQQQQQ-----------------QQQQQM--------QHLHQLQQL 46

  Fly   105 QQAQQQQL----YPHSHLFSPSAAEYGITTSTTTGNPGTPLHPSSHSPADSYYESDSVHSYYATA 165
            ||..||||    :.|..:...:||......:..          ::|:.|.:..:..|     .:.
  Fly    47 QQLHQQQLAAGVFHHPAMAFDAAAAAAAAAAAA----------AAHAHAAALQQRLS-----GSG 96

  Fly   166 AVATVAPPSNSSPITAANASATS-----------NTQQQQQQAAIISSENGMMYTNLDCMYPTAQ 219
            :.|:.:.|::|:|:|.....:.|           :|..::::|    .|:..:..::|......:
  Fly    97 SPASCSTPASSTPLTIKEEESDSVIGDMSFHNQTHTTNEEEEA----EEDDDIDVDVDDTSAGGR 157

  Fly   220 AQAPVH------------GYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQ--QATQSQM------ 264
            ...|.|            ..:..:.:::..|    ..||..:|:|..:.:  :|::||.
  Fly   158 LPPPAHQQQSTAKPSLAFSISNILSDRFGDV----QKPGKSMENQASIFRPFEASRSQTATPSAF 218

  Fly   265 -------WHHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQ 322
                   :..||..|.:.|..||           .|...:..|..|
  Fly   219 TRVDLLEFSRQQQAAAAAATAAM-----------MLERANFLNCFN------------------- 253

  Fly   323 PQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISP----------------GSSTSSSTSASN 371
                    |||:.:.|:..|...  :.|.....||.|                ||...:.:....
  Fly   254 --------PAAYPRIHEEIVQSR--LRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQ 308

  Fly   372 GAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGG 436
            .|.|..||....:.:||:.:          |.|.:   .||.|:|......:.. ....|.....
  Fly   309 PAAPTMTQPPLSSSASSLAS----------PPPAS---NASTISSTSSVATSSS-SSSSGCSSAA 359

  Fly   437 SGVGNGP---VGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSS----- 493
            |.:.:.|   :|..|:|.    ...|.|...|...||.:..|...:.......:||..:.
  Fly   360 SSLNSSPSSRLGASGSGV----NASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNE 420

  Fly   494 -------CSLSSNTNNSG-------------------RTNFTNKQLTELEKEFHFNRYLTRARRI 532
                   |:..|:..:||                   ||.|:::||..|::||:.|||||..||.
  Fly   421 MWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQ 485

  Fly   533 EIANTLQLNETQVKIWFQNRRMKQKKRV--KEGL---IPADILTQHSTSVISEKPPQQQQPQPPE 592
            ::::.|.|||.|:||||||:|.|.||..  |..|   :.|..|..|:|..:::        :..|
  Fly   486 QLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTK--------EEEE 542

  Fly   593 LQLKSQG 599
            |:::..|
  Fly   543 LEMRMNG 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	28/52 (54%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	28/55 (51%)
		Engrail_1_C_sig	512..542	CDD:431338	6/37 (16%)