Protein Alignment lab and Lim3

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001260559.1
• Gene: Lim3 / 35184
• FlyBaseID: FBgn0002023
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 117/609 - (19%)
• Similarity: 178/609 - (29%)
• Gaps: 248/609 - (40%)

  Fly    13 HHHHPHANAYDGYSTTTASAANASSYFAPQQHQPHLQLQQQQQHQHLQQPQQHLT-YNGYESSSP 76
            ||||.|.:...                .|.|.|||    ..||.||..|.||||: .:.::...|
  Fly    12 HHHHQHQHQLQ----------------HPPQQQPH----PHQQLQHPLQQQQHLSAMDNHQQHQP 56

  Fly    77 GNYYPQQQAQLTPP-PTSSHQVVQQHQQQQQAQQQQLYPHSHLFSPSAAEYGITTSTTTGNPGTP 140
            ..:..|||.|..|| |.:||.|..|.||||...      |:||          .......||...
  Fly    57 HIHQQQQQQQQLPPTPQASHLVGGQQQQQQHPH------HNHL----------AVDQDDPNPELV 105

  Fly   141 LHPSSHSPA---------------------------------------------------DSYYE 154
            |...|.:.|                                                   ..:.:
  Fly   106 LALISRNRALEATIPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCK 170

  Fly   155 SDSVHSYYATAAVATVA-PPS-----------NSSPITAANASATSNTQQQ---QQQAAII---- 200
            .|....|....:...:. ||:           :......|..|.|.||..:   .:...:|
  Fly   171 EDFFKRYGTKCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRD 235

  Fly   201 ---SSENGM-MYTNLDCMYPTAQAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQAT- 260
               :...|: :..:||...|..:.:..:  .|.|:|....| .:.|..|...:.:|   :.|.|
  Fly   236 YEEAKAKGLYLDGSLDGDQPNKRPRTTI--TAKQLETLKTA-YNNSPKPARHVREQ---LSQDTG 294

  Fly   261 ----QSQMWHHQQH---------------------LAGSYA------LDAMDSLGM--HAHMHHG 292
                ..|:|...:.                     :.|:.:      || .|.|.:  .:..||.
  Fly   295 LDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSPRTDKFLD-KDELKVDYDSFSHHD 358

  Fly   293 L-----------------PHGHLGNL---ANNPHQQQPQVQQQQQ--QPHQQPQHPQN------- 328
            |                 ||...|:.   :::|.|..|..:....  |.|....:|.|
  Fly   359 LSNDSYSTVNLGLDEGASPHSIRGSYMHGSSSPSQYPPSSRSPPPVGQGHTFGSYPDNIVYTNID 423

  Fly   329 --------QSPAAHQQHHQNSVSPNGGMNRQQRGGVISP--------GSSTSSSTSASNGAHPAS 377
                    .|.|.|:.|..|:||.....:...:|....|        .|.::::|||:|.|:..|
  Fly   424 QAVGSSLHASKAHHRLHSSNNVSDLSNDSSPDQGYPDFPPSPDSWLGDSGSTNTTSANNNANNNS 488

  Fly   378 TQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNG 442
            :.|.:.|:||                                           |||.||..|...
  Fly   489 SSSHNNNNSS-------------------------------------------GGGSGGVSVSTA 510

  Fly   443 PVGVGGNGSPGIGGVLSVQNSLIM 466
            |       :|...||....::|::
  Fly   511 P-------NPSAPGVHYXYSNLLL 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	0/50 (0%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	8/54 (15%)
		Homeodomain	257..313	CDD:459649	11/61 (18%)