Protein Alignment lab and EVX2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001073927.1
• Gene: EVX2 / 344191
• HGNCID: 3507
• Length: 476
• Species: Homo sapiens
• Alignment Length: 342
• Identity: 82/342 - (23%)
• Similarity: 124/342 - (36%)
• Gaps: 133/342 - (38%)

  Fly   247 MVLEDQDPMMQQATQSQMWHHQQHLAGSYALDAMDSLGMHAHMHHGLP----HGHLGNLA----- 302
            |:|.::.  :...|..:.:.:..:.||:..|:|:::....|.:...||    |..||.|.
Human     9 MILMERG--LHSPTAGKRFSNLSNSAGNAVLEALENSQHPARLSPRLPSAPLHSALGELPAKGKF 71

  Fly   303 ------NNPHQ-QQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSV--------SPNGGMN--- 349
                  |..|. .:..|..:.....:..:.|.:.|.||.:....:.|        || ||:.
Human    72 EIDTLFNLQHTGSESTVSSEISSAAESRKKPGHYSEAAAEADMSSDVEVGCSALRSP-GGLGAAQ 135

  Fly   350 -RQQRG-GVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPAS 412
             ::..| |....||:..::||||                                        .|
Human   136 LKENNGKGYAESGSAAGTTTSAS----------------------------------------GS 160

  Fly   413 GIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAH 477
            |:.|:|             ||.||||           ||..:|
Human   161 GLGSLH-------------GGSGGSG-----------GSAALG---------------------- 179

  Fly   478 PNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNE 542
                    |||||       ::.....||.||.:|:..|||||:...|::|.||.|:|..|.|.|
Human   180 --------GSGSG-------ADQVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPE 229

  Fly   543 TQVKIWFQNRRMKQKKR 559
            |.:|:||||||||.|::
Human   230 TTIKVWFQNRRMKDKRQ 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	29/52 (56%)
EVX2	NP_001073927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..113		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..185		25/143 (17%)
		Homeodomain	189..245	CDD:459649	29/55 (53%)