Protein Alignment lab and HOXA10

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_061824.3
• Gene: HOXA10 / 3206
• HGNCID: 5100
• Length: 410
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 121/510 - (23%)
• Similarity: 160/510 - (31%)
• Gaps: 203/510 - (39%)

  Fly   139 TPLHPS----SHSPADSYYESDSVHS--------------------YYATAAVATVAPPSNSSPI 179
            :|.:|:    |.|||.:.:..||:.|                    |||...|  ..||:...|
Human    11 SPNYPTTMSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAHGGV--YLPPAADLP- 72

  Fly   180 TAANASATSNTQQQQQQAAIISSENGMMYTNLDC-MYPTA-----QAQAPVHGYAGQIEEKYAAV 238
                                        |....| ::||.     :|.:|..|..|
Human    73 ----------------------------YGLQSCGLFPTLGGKRNEAASPGSGGGG--------- 100

  Fly   239 LHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLAN 303
              ....||.......|:       .:|           |||..|..|
Human   101 --GGLGPGAHGYGPSPI-------DLW-----------LDAPRSCRM------------------ 127

  Fly   304 NPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTS 368
            .|....|...|||..|..||..|..|:.:.       |.:.|           |...||.....|
Human   128 EPPDGPPPPPQQQPPPPPQPPQPAPQATSC-------SFAQN-----------IKEESSYCLYDS 174

  Fly   369 ASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLP-------ASGIASMHDYQMNGQL 426
            |          .|.|..|::....        .|.|:.|. |       :||:.....::::...
Human   175 A----------DKCPKVSATAAEL--------APFPRGPP-PDGCALGTSSGVPVPGYFRLSQAY 220

  Fly   427 DMCRG---GGGGGSGVGNGPV-----GVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGV 483
            ...:|   ||||...:|.||.     |.|.:..|.:     ...|...|....|..|..|..:..
Human   221 GTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPAL-----ASGSADAARKERALDSPPPPTLAC 280

  Fly   484 GLGSGS---------------------------------GLSSCSLSSN--TNNSGRTN---FTN 510
            |.|.||                                 |.|....::|  |..|||..   :|.
Human   281 GSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTK 345

  Fly   511 KQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLI 565
            .|..||||||.||.||||.||:||:.::.|.:.||||||||||||.||..:|..|
Human   346 HQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRI 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	32/55 (58%)
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..158		23/122 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..339		27/122 (22%)
		Homeodomain	337..393	CDD:459649	32/55 (58%)