DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and HOXA4

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_002132.3	Gene:	HOXA4 / 3201	HGNCID:	5105	Length:	320	Species:	Homo sapiens

Alignment Length:	347	Identity:	97/347 - (27%)
Similarity:	130/347 - (37%)	Gaps:	106/347 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 HMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQ 352
            :..|....|..|.....|..|||.....|..|.||||.|                         .
Human    23 YAQHSGSGGADGGPGGGPGYQQPPAPPTQHLPLQQPQLP-------------------------H 62

  Fly   353 RGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTYKW----MQLKRNVPKPQAP----KL 409
            .||...|.:|..:..:|...|:||:  :..|.|.::...|.:    .......|:|:.|    |.
Human    63 AGGGREPTASYYAPRTAREPAYPAA--ALYPAHGAADTAYPYGYRGGASPGRPPQPEQPPAQAKG 125

  Fly   410 PASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAG 474
            ||.|:.:.|..|                              |.:...|..:.....|.....|.
Human   126 PAHGLHASHVLQ------------------------------PQLPPPLQPRAVPPAAPRRCEAA 160

  Fly   475 SAHPNGMGVGLGSGSGLSSCSL---------------------------SSNTNNSG------RT 506
            .|.|     |:.:|....:|.|                           :.|.:.:|      ||
Human   161 PATP-----GVPAGGSAPACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNPSYNGGEPKRSRT 220

  Fly   507 NFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILT 571
            .:|.:|:.||||||||||||||.||||||:||.|:|.||||||||||||.||..|   :|...:.
Human   221 AYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHK---LPNTKMR 282

  Fly   572 QHSTSVISEKPPQQQQPQPPEL 593
            ..:::..|..||.:.|.|.|.|
Human   283 SSNSASASAGPPGKAQTQSPHL 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	40/51 (78%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..77		18/78 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..168		16/101 (16%)
		Antp-type hexapeptide	194..199		0/4 (0%)
		Homeobox	218..271	CDD:278475	40/52 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..320		9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810