DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and HOXA3

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	509	Identity:	118/509 - (23%)
Similarity:	160/509 - (31%)	Gaps:	230/509 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SYYESDSVHSYYATAAVATVAPPSNSSPITAANASATSNTQQQQQQAAIISSENGMMYTNLDCMY 215
            :||:|.:::..|               |..|||..|.:..||....:|.:.::.       :...
Human     5 TYYDSSAIYGGY---------------PYQAANGFAYNANQQPYPASAALGADG-------EYHR 47

  Fly   216 PTAQAQAPV----HGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYA 276
            |....|:|.    |..|.::.|   |.|....||    ..|.|
Human    48 PACSLQSPSSAGGHPKAHELSE---ACLRTLSAP----PSQPP---------------------- 83

  Fly   277 LDAMDSLGMHAHMHHGLPHGHLGNLANNP--HQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQ 339
                 |||                   .|  |...||......||.|....|...:|||.
Human    84 -----SLG-------------------EPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAP----- 119

  Fly   340 NSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPT-----YKWMQLKR 399
                              .|.||.|...:|||...||:. :|||..:|  ||     :.||:..|
Human   120 ------------------PPPSSASPPQNASNNPTPANA-AKSPLLNS--PTVAKQIFPWMKESR 163

  Fly   400 NVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSL 464
            ...|                                                         |.:.
Human   164 QNTK---------------------------------------------------------QKTS 171

  Fly   465 IMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRA 529
            ..::..:.||...|.|..                 ::...||.:|:.||.||||||||||||.|.
Human   172 SSSSGESCAGDKSPPGQA-----------------SSKRARTAYTSAQLVELEKEFHFNRYLCRP 219

  Fly   530 RRIEIANTLQLNETQVKIWFQNRRMKQKKRVK-EGLIPAD-----------------ILTQHS-- 574
            ||:|:||.|.|.|.|:||||||||||.||..| :|::.:.                 :.:.||
Human   220 RRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLV 284

  Fly   575 TSVISE--------KPPQQ----------------QQPQPPELQLKSQGSDLGG 604
            .||..|        ||||.                ..|.||:.:..:.|:..||
Human   285 NSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	37/51 (73%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		30/145 (21%)
		Antp-type hexapeptide	155..160		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		8/110 (7%)
		Homeobox	195..248	CDD:395001	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		17/90 (19%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810