Protein Alignment lab and HOXA1

DIOPT Version :9

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_005513.2
• Gene: HOXA1 / 3198
• HGNCID: 5099
• Length: 335
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 136/519 - (26%)
• Similarity: 182/519 - (35%)
• Gaps: 212/519 - (40%)

  Fly   122 SAAEYGITTSTTTGNPGTPLHPSSHSPADSYYESDSVHSYYATAAVATVAPPSNSSPITAANASA 186
            |..||.|.:|..:|......:||.|.           .:.:.:.||:..:...:...:.......
Human     8 SFLEYPILSSGDSGTCSARAYPSDHR-----------ITTFQSCAVSANSCGGDDRFLVGRGVQI 61

  Fly   187 TS------NTQQQQQQAAIISSEN-GMMYTNLDC--MYPTAQAQAPVHGYA----GQIEEKYAAV 238
            .|      :..:..|.|...:|.| |:.|::..|  .|.:....||...||    ..:...|...
Human    62 GSPHHHHHHHHRHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVSGGYPQC 126

  Fly   239 LHASYAPGMVLEDQDPMMQQATQSQMWHHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLAN 303
            ..|.|:..:    ..||:|.      .||.|..||.       ::|...::||.....|
Human   127 APAVYSGNL----SSPMVQH------HHHHQGYAGG-------AVGSPQYIHHSYGQEH------ 168

  Fly   304 NPHQQQPQVQQQQQQPHQQPQHPQNQSPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTS 368
                                     ||.|.  ..:.||:||   ::...:....||.|.|||
Human   169 -------------------------QSLAL--ATYNNSLSP---LHASHQEACRSPASETSS--- 200

  Fly   369 ASNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGG 433
                  ||.             |:.||::|||.||
Human   201 ------PAQ-------------TFDWMKVKRNPPK------------------------------ 216

  Fly   434 GGGSGVGNGPVG-VGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGLGSGSGLSSCSLS 497
                   .|.|| .|..|.|
Human   217 -------TGKVGEYGYLGQP--------------------------------------------- 229

  Fly   498 SNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKE 562
                |:.|||||.|||||||||||||:|||||||:|||.:||||||||||||||||||||||.||
Human   230 ----NAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKE 290

  Fly   563 GLIPADILTQHSTSVISEKPPQQQQPQPPELQLKSQGSDLGGNELATGAPSTP----TTAMTLT 622
            ||:|....|                  ||....|::.|    :|.::.:|..|    :|:.|||
Human   291 GLLPISPAT------------------PPGNDEKAEES----SEKSSSSPCVPSPGSSTSDTLT 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	46/51 (90%)
HOXA1	NP_005513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..83		3/21 (14%)
		Interaction with OGT. /evidence=ECO:0000250|UniProtKB:P09022	75..203		41/189 (22%)
		COG5576	176..>286	CDD:227863	74/220 (34%)
		Antp-type hexapeptide	204..209		2/4 (50%)
		Homeobox	233..286	CDD:365835	47/52 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..335		24/74 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6704
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4334
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003011
OrthoInspector	1	1.000	-	-		otm41441
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45946
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2567
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.180