Protein Alignment lab and Nkx6-2

DIOPT Version :10

• Sequence 1: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001101028.1
• Gene: Nkx6-2 / 309095
• RGDID: 1307280
• Length: 277
• Species: Rattus norvegicus
• Alignment Length: 223
• Identity: 61/223 - (27%)
• Similarity: 88/223 - (39%)
• Gaps: 53/223 - (23%)

  Fly   404 PQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNG----SPGIGGVLSVQNSL 464
            |...|.||.|       .:..||.:  |...|.|.:...|||..|.|    .|.:.|:.|  ::.
  Rat    37 PAGFKTPALG-------SLGAQLPL--GTPHGISDILGRPVGAAGGGLLGSLPRLNGLAS--SAG 90

  Fly   465 IMANSAAAAGSAHPNGMG----------VGLGSGSGLSSCSLSSNTNNSG-----------RTNF 508
            :....|||....:|..:.          .|:..||......|:.:....|           |..|
  Rat    91 VYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGSPWRDPRLAGSAQAGGVLDKDGKKKHSRPTF 155

  Fly   509 TNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADILTQH 573
            :.:|:..|||.|...:||....|..:|.:|.:.|:|||:||||||.|.:||             |
  Rat   156 SGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKR-------------H 207

  Fly   574 STSVISEKPPQQQQPQPPELQLKSQGSD 601
            :..:.|.|..|....:    :||..|||
  Rat   208 AAEMASAKKKQDSDAE----KLKVGGSD 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	23/52 (44%)
Nkx6-2	NP_001101028.1	Homeodomain	147..205	CDD:459649	23/57 (40%)