DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lab and hoxa2b

DIOPT Version :9

Sequence 1:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_571181.1	Gene:	hoxa2b / 30325	ZFINID:	ZDB-GENE-990415-98	Length:	363	Species:	Danio rerio

Alignment Length:	323	Identity:	84/323 - (26%)
Similarity:	114/323 - (35%)	Gaps:	125/323 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 SSTSSST----------------SASNGAHPASTQSK-SPNHSSSIPT------YKWMQLKRNVP 402
            ||..|||                |.:.|:||..::.| :||.|..:|.      |.||:.|:...
Zfish    35 SSIKSSTLSHSTLIPPPFEQTIPSLNPGSHPRHSRPKQNPNGSCPLPAASLPPEYPWMKEKKASK 99

  Fly   403 KPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMA 467
            |.|.....|:                          ...||:.....|||.|.
Zfish   100 KNQTTSTAAT--------------------------TDPGPLYFSPQGSPEIS------------ 126

  Fly   468 NSAAAAGSAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRI 532
                              ..|||         .....||.:||.||.|||||||||:||.|.||:
Zfish   127 ------------------DGGSG---------ATRRLRTAYTNTQLLELEKEFHFNKYLCRPRRV 164

  Fly   533 EIANTLQLNETQVKIWFQNRRMKQKKRVK-------EGLIPA--------------DILTQHSTS 576
            |||..|.|.|.|||:||||||||.|::.:       :|..|:              :.:..:.:.
Zfish   165 EIAALLDLTERQVKVWFQNRRMKHKRQTQCKENHHGDGKPPSLEEAGGRGDGKSFFEQVANNVSG 229

  Fly   577 VISEKP--PQQQQPQPPELQLKSQGSD--------LGGNE-----LATGAPSTPTTAMTLTAP 624
            .:.|:.  |.||.....:.......||        ||.|:     ....:|:.|....|: ||
Zfish   230 ALLEREGYPFQQNTLTSQQSQNGHNSDSQSATVSPLGSNDKHLKHFPNPSPTVPICTTTM-AP 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lab	NP_476613.1	Homeobox	505..557	CDD:278475	37/51 (73%)
hoxa2b	NP_571181.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..132		25/154 (16%)
		Antp-type hexapeptide	88..93		2/4 (50%)
		Homeobox	137..189	CDD:278475	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..218		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..279		5/33 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900